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Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle

Mitochondrial malate dehydrogenase (MDH)-citrate synthase (CS) multi-enzyme complex is a part of the Krebs tricarboxylic acid (TCA) cycle ‘metabolon’ which is enzyme machinery catalyzing sequential reactions without diffusion of reaction intermediates into a bulk matrix. This complex is assumed to b...

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Detalles Bibliográficos
Autores principales: Omini, Joy, Wojciechowska, Izabela, Skirycz, Aleksandra, Moriyama, Hideaki, Obata, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455617/
https://www.ncbi.nlm.nih.gov/pubmed/34548590
http://dx.doi.org/10.1038/s41598-021-98314-z