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Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway

Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies. However, lack of tumor-specific targets and the existence of inhibitory factors limit the function of CA...

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Detalles Bibliográficos
Autores principales:	Gao, Yaoxin, Lin, Haizhen, Guo, Dandan, Cheng, Sijia, Zhou, Ying, Zhang, Li, Yao, Jie, Farooq, Muhammad Asad, Ajmal, Iqra, Duan, Yixin, He, Cong, Tao, Lei, Wu, Shijia, Liu, Mingyao, Jiang, Wenzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455638/ https://www.ncbi.nlm.nih.gov/pubmed/34548478 http://dx.doi.org/10.1038/s41389-021-00353-8

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