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Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences

AIM: The optimal diagnostic test in the work-up of suspected acute coronary syndrome (ACS) may differ between men and women. The aim of this study was to compare sex-associated differences between using a diagnostic strategy including early coronary computed tomography angiography (CCTA) and standar...

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Autores principales: Arslan, M., Schaap, J., Moelker, A., Rood, P. P. M., Boersma, E., Nieman, K., Dubois, E. A., Dedic, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bohn Stafleu van Loghum 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455783/
https://www.ncbi.nlm.nih.gov/pubmed/34357558
http://dx.doi.org/10.1007/s12471-021-01607-1
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author Arslan, M.
Schaap, J.
Moelker, A.
Rood, P. P. M.
Boersma, E.
Nieman, K.
Dubois, E. A.
Dedic, A.
author_facet Arslan, M.
Schaap, J.
Moelker, A.
Rood, P. P. M.
Boersma, E.
Nieman, K.
Dubois, E. A.
Dedic, A.
author_sort Arslan, M.
collection PubMed
description AIM: The optimal diagnostic test in the work-up of suspected acute coronary syndrome (ACS) may differ between men and women. The aim of this study was to compare sex-associated differences between using a diagnostic strategy including early coronary computed tomography angiography (CCTA) and standard of care (SOC). METHODS: In total, 500 patients who presented with symptoms suggestive of ACS at the emergency department were randomised between a diagnostic strategy supplemented with early CCTA and SOC. RESULTS: Women were generally older than men (mean ± standard deviation 56 ± 10 vs 53 ± 10 years, p < 0.01) and were less often admitted to hospital (33% vs 44%, p = 0.02). Obstructive coronary artery disease on CCTA (> 50% luminal narrowing) was less frequently seen in women (14% vs 26%, p = 0.02), and ACS was diagnosed less often in women (5% vs 10%, p = 0.03). Women underwent less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS (p = 0.008). CONCLUSION: Women had a lower incidence of obstructive CAD on CCTA and were less often admitted to hospital than men. They were subjected to less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12471-021-01607-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-84557832021-10-07 Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences Arslan, M. Schaap, J. Moelker, A. Rood, P. P. M. Boersma, E. Nieman, K. Dubois, E. A. Dedic, A. Neth Heart J Original Article AIM: The optimal diagnostic test in the work-up of suspected acute coronary syndrome (ACS) may differ between men and women. The aim of this study was to compare sex-associated differences between using a diagnostic strategy including early coronary computed tomography angiography (CCTA) and standard of care (SOC). METHODS: In total, 500 patients who presented with symptoms suggestive of ACS at the emergency department were randomised between a diagnostic strategy supplemented with early CCTA and SOC. RESULTS: Women were generally older than men (mean ± standard deviation 56 ± 10 vs 53 ± 10 years, p < 0.01) and were less often admitted to hospital (33% vs 44%, p = 0.02). Obstructive coronary artery disease on CCTA (> 50% luminal narrowing) was less frequently seen in women (14% vs 26%, p = 0.02), and ACS was diagnosed less often in women (5% vs 10%, p = 0.03). Women underwent less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS (p = 0.008). CONCLUSION: Women had a lower incidence of obstructive CAD on CCTA and were less often admitted to hospital than men. They were subjected to less outpatient testing when early CCTA was used in the emergency department evaluation of suspected ACS. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12471-021-01607-1) contains supplementary material, which is available to authorized users. Bohn Stafleu van Loghum 2021-08-06 2021-10 /pmc/articles/PMC8455783/ /pubmed/34357558 http://dx.doi.org/10.1007/s12471-021-01607-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Arslan, M.
Schaap, J.
Moelker, A.
Rood, P. P. M.
Boersma, E.
Nieman, K.
Dubois, E. A.
Dedic, A.
Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title_full Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title_fullStr Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title_full_unstemmed Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title_short Coronary CT angiography for suspected acute coronary syndrome: sex-associated differences
title_sort coronary ct angiography for suspected acute coronary syndrome: sex-associated differences
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455783/
https://www.ncbi.nlm.nih.gov/pubmed/34357558
http://dx.doi.org/10.1007/s12471-021-01607-1
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