Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

The multifunctional nature of human flavoproteins is critically linked to their ability to populate multiple conformational states. Ligand binding, post-translational modifications and disease-associated mutations can reshape this functional landscape, although the structure-function relationships o...

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Detalles Bibliográficos
Autores principales: Pacheco-Garcia, Juan Luis, Anoz-Carbonell, Ernesto, Vankova, Pavla, Kannan, Adithi, Palomino-Morales, Rogelio, Mesa-Torres, Noel, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455868/
https://www.ncbi.nlm.nih.gov/pubmed/34537677
http://dx.doi.org/10.1016/j.redox.2021.102112

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