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Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease

Cerebral small vessel disease (SVD) refers to a heterogeneous group of pathological processes that result from damage to the small penetrating vessels in the brain. Spatial navigation, one of the most fundamental behaviors, has lately attracted considerable clinical interest. This study aimed to det...

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Autores principales: Zhào, Hóngyi, Chi, Liyi, Zhang, Yanhai, Huang, Yonghua, Tian, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455869/
https://www.ncbi.nlm.nih.gov/pubmed/34566827
http://dx.doi.org/10.3389/fneur.2021.608797
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author Zhào, Hóngyi
Chi, Liyi
Zhang, Yanhai
Huang, Yonghua
Tian, Hongyan
author_facet Zhào, Hóngyi
Chi, Liyi
Zhang, Yanhai
Huang, Yonghua
Tian, Hongyan
author_sort Zhào, Hóngyi
collection PubMed
description Cerebral small vessel disease (SVD) refers to a heterogeneous group of pathological processes that result from damage to the small penetrating vessels in the brain. Spatial navigation, one of the most fundamental behaviors, has lately attracted considerable clinical interest. This study aimed to determine whether spatial navigation performance is impaired in elderly SVD patients. In total, 18 elderly patients with severe SVD, 40 elderly patients with non-severe SVD, and 41 age-matched healthy volunteers were classified according to the Fazekas scale. Spatial navigation was evaluated by Amunet (a computer-based analogy of Morris water maze software), and a mini-mental scale evaluation (MMSE), animal category verbal fluency test (VFT), clock drawing test (CDT), and trail making test (TMT) -B were also applied. Compared to healthy controls, severe SVD, rather than non-severe SVD patients, exhibited significantly worse performance on “allocentric + egocentric” (41.74 ± 29.10 vs. 31.50 ± 16.47 vs. 29.21 ± 19.03; p = 0.031). Furthermore, the different abilities of spatial navigation among groups reached a statistical level on allocentric subtests (46.93 ± 31.27 vs. 43.69 ± 23.95 vs. 28.56 ± 16.38; p = 0.003), but not on egocentric subtest (56.16 ± 39.85 vs. 56.00 ± 28.81 vs. 43.06 ± 25.07; p = 0.105). The linear regression analysis revealed that allocentric navigation deficit was significantly correlated with TMT-B (p = 0.000, standardized β = 0.342) and VFT (p = 0.016, standardized β = −0.873) performance in elderly SVD patients. These results elucidated that spatial navigation ability could be a manifestation of cognitive deficits in elderly patients with SVD.
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spelling pubmed-84558692021-09-23 Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease Zhào, Hóngyi Chi, Liyi Zhang, Yanhai Huang, Yonghua Tian, Hongyan Front Neurol Neurology Cerebral small vessel disease (SVD) refers to a heterogeneous group of pathological processes that result from damage to the small penetrating vessels in the brain. Spatial navigation, one of the most fundamental behaviors, has lately attracted considerable clinical interest. This study aimed to determine whether spatial navigation performance is impaired in elderly SVD patients. In total, 18 elderly patients with severe SVD, 40 elderly patients with non-severe SVD, and 41 age-matched healthy volunteers were classified according to the Fazekas scale. Spatial navigation was evaluated by Amunet (a computer-based analogy of Morris water maze software), and a mini-mental scale evaluation (MMSE), animal category verbal fluency test (VFT), clock drawing test (CDT), and trail making test (TMT) -B were also applied. Compared to healthy controls, severe SVD, rather than non-severe SVD patients, exhibited significantly worse performance on “allocentric + egocentric” (41.74 ± 29.10 vs. 31.50 ± 16.47 vs. 29.21 ± 19.03; p = 0.031). Furthermore, the different abilities of spatial navigation among groups reached a statistical level on allocentric subtests (46.93 ± 31.27 vs. 43.69 ± 23.95 vs. 28.56 ± 16.38; p = 0.003), but not on egocentric subtest (56.16 ± 39.85 vs. 56.00 ± 28.81 vs. 43.06 ± 25.07; p = 0.105). The linear regression analysis revealed that allocentric navigation deficit was significantly correlated with TMT-B (p = 0.000, standardized β = 0.342) and VFT (p = 0.016, standardized β = −0.873) performance in elderly SVD patients. These results elucidated that spatial navigation ability could be a manifestation of cognitive deficits in elderly patients with SVD. Frontiers Media S.A. 2021-09-08 /pmc/articles/PMC8455869/ /pubmed/34566827 http://dx.doi.org/10.3389/fneur.2021.608797 Text en Copyright © 2021 Zhào, Chi, Zhang, Huang and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhào, Hóngyi
Chi, Liyi
Zhang, Yanhai
Huang, Yonghua
Tian, Hongyan
Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title_full Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title_fullStr Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title_full_unstemmed Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title_short Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease
title_sort spatial navigation is impaired in elderly patients with cerebral small vessel disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455869/
https://www.ncbi.nlm.nih.gov/pubmed/34566827
http://dx.doi.org/10.3389/fneur.2021.608797
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