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Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics

An inkjet-printed paper-based Surface-enhanced Raman scattering (SERS) sensor is a robust and versatile device that provides trace sensing capabilities for the detection and analysis of narcotics and drugs. Such sensors generally work well for analytes with good binding affinity towards the Au or Ag...

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Autores principales: Tay, Li-Lin, Poirier, Shawn, Ghaemi, Ali, Hulse, John, Wang, Shiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455876/
https://www.ncbi.nlm.nih.gov/pubmed/34568274
http://dx.doi.org/10.3389/fchem.2021.680556
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author Tay, Li-Lin
Poirier, Shawn
Ghaemi, Ali
Hulse, John
Wang, Shiliang
author_facet Tay, Li-Lin
Poirier, Shawn
Ghaemi, Ali
Hulse, John
Wang, Shiliang
author_sort Tay, Li-Lin
collection PubMed
description An inkjet-printed paper-based Surface-enhanced Raman scattering (SERS) sensor is a robust and versatile device that provides trace sensing capabilities for the detection and analysis of narcotics and drugs. Such sensors generally work well for analytes with good binding affinity towards the Au or Ag plasmonic nanoparticles (NPs) resident in the sensors. In this report, we show that iodide functionalization of the printed sensors helps to remove adsorbed contaminants from AuNP surfaces enabling superior performance with improved detection of narcotics such as fentanyl, heroin and cocaine by SERS. SERS signals are easily doubled with the iodide-functionalized sensors which also showed orders of magnitude improvement in detection limit. In this report, we show that a short (90 s) iodide treatment of the sensors significantly improved the detection of heroin. We propose that iodide functionalization be integrated into field detection kits through the solvent that wets paper-based sensor prior to swabbing for narcotics. Alternatively, we have also demonstrated that iodide functionalized sensors can be stored in ambient for up to 1 week and retain the improved performance towards heroin detection. This report will help to significantly improve the performance of paper-based sensors for field detection of narcotic drugs.
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spelling pubmed-84558762021-09-23 Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics Tay, Li-Lin Poirier, Shawn Ghaemi, Ali Hulse, John Wang, Shiliang Front Chem Chemistry An inkjet-printed paper-based Surface-enhanced Raman scattering (SERS) sensor is a robust and versatile device that provides trace sensing capabilities for the detection and analysis of narcotics and drugs. Such sensors generally work well for analytes with good binding affinity towards the Au or Ag plasmonic nanoparticles (NPs) resident in the sensors. In this report, we show that iodide functionalization of the printed sensors helps to remove adsorbed contaminants from AuNP surfaces enabling superior performance with improved detection of narcotics such as fentanyl, heroin and cocaine by SERS. SERS signals are easily doubled with the iodide-functionalized sensors which also showed orders of magnitude improvement in detection limit. In this report, we show that a short (90 s) iodide treatment of the sensors significantly improved the detection of heroin. We propose that iodide functionalization be integrated into field detection kits through the solvent that wets paper-based sensor prior to swabbing for narcotics. Alternatively, we have also demonstrated that iodide functionalized sensors can be stored in ambient for up to 1 week and retain the improved performance towards heroin detection. This report will help to significantly improve the performance of paper-based sensors for field detection of narcotic drugs. Frontiers Media S.A. 2021-09-08 /pmc/articles/PMC8455876/ /pubmed/34568274 http://dx.doi.org/10.3389/fchem.2021.680556 Text en Copyright © 2021 Tay, Poirier, Ghaemi, Hulse and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tay, Li-Lin
Poirier, Shawn
Ghaemi, Ali
Hulse, John
Wang, Shiliang
Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title_full Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title_fullStr Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title_full_unstemmed Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title_short Iodide Functionalized Paper-Based SERS Sensors for Improved Detection of Narcotics
title_sort iodide functionalized paper-based sers sensors for improved detection of narcotics
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455876/
https://www.ncbi.nlm.nih.gov/pubmed/34568274
http://dx.doi.org/10.3389/fchem.2021.680556
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