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Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis

Neutrophilic inflammation is a key determinant of cystic fibrosis (CF) lung disease. Neutrophil-derived free DNA, released in the form of extracellular traps (NETs), significantly correlates with impaired lung function in patients with CF, underlying their pathogenetic role in CF lung disease. Thus,...

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Detalles Bibliográficos
Autores principales:	Totani, Licia, Amore, Concetta, Piccoli, Antonio, Dell’Elba, Giuseppe, Di Santo, Angelo, Plebani, Roberto, Pecce, Romina, Martelli, Nicola, Rossi, Alice, Ranucci, Serena, De Fino, Ida, Moretti, Paolo, Bragonzi, Alessandra, Romano, Mario, Evangelista, Virgilio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456009/ https://www.ncbi.nlm.nih.gov/pubmed/34566635 http://dx.doi.org/10.3389/fphar.2021.702677

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