Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate tumorigenesis. Me...

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Detalles Bibliográficos
Autores principales: Guo, Jianping, Cheng, Ji, Zheng, Nana, Zhang, Xiaomei, Dai, Xiaoming, Zhang, Linli, Hu, Changjiang, Wu, Xueji, Jiang, Qiwei, Wu, Depei, Okada, Hitoshi, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456201/
https://www.ncbi.nlm.nih.gov/pubmed/34278744
http://dx.doi.org/10.1002/advs.202004303

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