Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications. However, the molecular mechanisms are mostly unknown, and a suitable animal model with internal increased ACR does not exist for in vivo studying so far. Several enzyme sy...

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Detalles Bibliográficos
Autores principales: Qi, Haozhe, Schmöhl, Felix, Li, Xiaogang, Qian, Xin, Tabler, Christoph T., Bennewitz, Katrin, Sticht, Carsten, Morgenstern, Jakob, Fleming, Thomas, Volk, Nadine, Hausser, Ingrid, Heidenreich, Elena, Hell, Rüdiger, Nawroth, Peter Paul, Kroll, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456208/
https://www.ncbi.nlm.nih.gov/pubmed/34278746
http://dx.doi.org/10.1002/advs.202101281

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