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Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing
Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)‐glycosaminoglycan (starPEG‐GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin wound model. Herein, a textile‐starPEG‐GAG compo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456214/ https://www.ncbi.nlm.nih.gov/pubmed/34278740 http://dx.doi.org/10.1002/advs.202100293 |
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author | Schirmer, Lucas Atallah, Passant Freudenberg, Uwe Werner, Carsten |
author_facet | Schirmer, Lucas Atallah, Passant Freudenberg, Uwe Werner, Carsten |
author_sort | Schirmer, Lucas |
collection | PubMed |
description | Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)‐glycosaminoglycan (starPEG‐GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin wound model. Herein, a textile‐starPEG‐GAG composite wound contact layer (WCL) capable of selectively sequestering pro‐inflammatory chemokines is reported. Systematic variation of the local and integral charge densities of the starPEG‐GAG hydrogel component allows for tailoring its affinity profile for biomolecular signals of the wound milieu. The composite WCL is subsequently tested in a large animal (porcine) model of human wound healing disorders. Dampening excessive inflammatory signals without affecting the levels of pro‐regenerative growth factors, the starPEG‐GAG hydrogel‐based WCL treatment induced healing with increased granulation tissue formation, angiogenesis, and deposition of connective tissue (collagen fibers). Thus, this biomaterials technology expands the scope of a new anti‐inflammatory therapy toward clinical use. |
format | Online Article Text |
id | pubmed-8456214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84562142021-09-27 Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing Schirmer, Lucas Atallah, Passant Freudenberg, Uwe Werner, Carsten Adv Sci (Weinh) Research Article Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)‐glycosaminoglycan (starPEG‐GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin wound model. Herein, a textile‐starPEG‐GAG composite wound contact layer (WCL) capable of selectively sequestering pro‐inflammatory chemokines is reported. Systematic variation of the local and integral charge densities of the starPEG‐GAG hydrogel component allows for tailoring its affinity profile for biomolecular signals of the wound milieu. The composite WCL is subsequently tested in a large animal (porcine) model of human wound healing disorders. Dampening excessive inflammatory signals without affecting the levels of pro‐regenerative growth factors, the starPEG‐GAG hydrogel‐based WCL treatment induced healing with increased granulation tissue formation, angiogenesis, and deposition of connective tissue (collagen fibers). Thus, this biomaterials technology expands the scope of a new anti‐inflammatory therapy toward clinical use. John Wiley and Sons Inc. 2021-07-18 /pmc/articles/PMC8456214/ /pubmed/34278740 http://dx.doi.org/10.1002/advs.202100293 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Schirmer, Lucas Atallah, Passant Freudenberg, Uwe Werner, Carsten Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title_full | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title_fullStr | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title_full_unstemmed | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title_short | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing |
title_sort | chemokine‐capturing wound contact layer rescues dermal healing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456214/ https://www.ncbi.nlm.nih.gov/pubmed/34278740 http://dx.doi.org/10.1002/advs.202100293 |
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