Innovating Clinical Trials for Amyotrophic Lateral Sclerosis: Challenging the Established Order

Development of effective treatments for amyotrophic lateral sclerosis (ALS) has been hampered by disease heterogeneity, a limited understanding of underlying pathophysiology, and methodologic design challenges. We have evaluated 2 major themes in the design of pivotal, phase 3 clinical trials for AL...

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Detalles Bibliográficos
Autores principales: van Eijk, Ruben P.A., Nikolakopoulos, Stavros, Roes, Kit C.B., Kendall, Lindsay, Han, Steve S., Lavrov, Arseniy, Epstein, Noam, Kliest, Tessa, de Jongh, Adriaan D., Westeneng, Henk-Jan, Al-Chalabi, Ammar, Van Damme, Philip, Hardiman, Orla, Shaw, Pamela J., McDermott, Christopher J., Eijkemans, Marinus J.C., van den Berg, Leonard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Contemporary Issues in Practice, Education, & Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456357/
https://www.ncbi.nlm.nih.gov/pubmed/34315786
http://dx.doi.org/10.1212/WNL.0000000000012545

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