Cargando…

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jing, Yukai, Luo, Li, Chen, Ying, Westerberg, Lisa S., Zhou, Peng, Xu, Zhiping, Herrada, Andrés A., Park, Chan-Sik, Kubo, Masato, Mei, Heng, Hu, Yu, Lee, Pamela Pui-Wah, Zheng, Bing, Sui, Zhiwei, Xiao, Wei, Gong, Quan, Lu, Zhongxin, Liu, Chaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456405/ https://www.ncbi.nlm.nih.gov/pubmed/34552055 http://dx.doi.org/10.1038/s41392-021-00749-3

Ejemplares similares

The role of B cells in COVID-19 infection and vaccination
por: Chen, Shiru, et al.
Publicado: (2022)

Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2
por: Zhu, Yingzi, et al.
Publicado: (2022)

The regulators of BCR signaling during B cell activation
por: Wen, Yue, et al.
Publicado: (2019)

Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells
por: Yang, Lu, et al.
Publicado: (2020)

Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis
por: Niu, LinLin, et al.
Publicado: (2018)

Corrigendum: Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis
por: Niu, LinLin, et al.
Publicado: (2020)

The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice
por: Zheng, Bing, et al.
Publicado: (2018)

The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation
por: Li, Jingwen, et al.
Publicado: (2019)

N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling
por: Liu, Chaohong, et al.
Publicado: (2013)

Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse
por: Mastio, Jérôme, et al.
Publicado: (2020)

Simulation of the Dynamics of Primary Immunodeficiencies in B Cells
por: Teku, Gabriel Ndipagbornchi, et al.
Publicado: (2018)

Congenital Defects in Actin Dynamics of Germinal Center B Cells
por: He, Minghui, et al.
Publicado: (2019)

The Unknown Unknowns: Recovering Gamma-Delta T Cells for Control of Human Immunodeficiency Virus (HIV)
por: Biradar, Shivkumar, et al.
Publicado: (2020)

Downregulation of TACC3 inhibits tumor growth and migration in osteosarcoma cells through regulation of the NF-κB signaling pathway
por: Zhao, Congran, et al.
Publicado: (2018)

MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability
por: Liu, Jin-Xin, et al.
Publicado: (2023)

The role of regulatory T cells and follicular T helper cells in HBV infection
por: Lin, Nengqi, et al.
Publicado: (2023)

Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation
por: Seeley-Fallen, Margaret K., et al.
Publicado: (2022)

Strategies for B-Cell Receptor Repertoire Analysis in Primary Immunodeficiencies: From Severe Combined Immunodeficiency to Common Variable Immunodeficiency
por: IJspeert, Hanna, et al.
Publicado: (2015)

T(o) be, or (not) to B, or both? Somatically mutated clonal T cells in common variable immunodeficiency and related immunodeficiencies
por: Ishida, Fumihiro, et al.
Publicado: (2020)

miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1
por: Long, Jingpei, et al.
Publicado: (2015)

B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency
por: Fekrvand, Saba, et al.
Publicado: (2022)

Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future
por: Ahmed, Aisha, et al.
Publicado: (2022)

Extracellular Matrix can Recover the Downregulation of Adhesion Molecules after Cell Detachment and Enhance Endothelial Cell Engraftment
por: He, Ningning, et al.
Publicado: (2015)

Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling
por: Gu, Heng, et al.
Publicado: (2023)

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions
por: Tan, Diaoyi, et al.
Publicado: (2022)

Primary immunodeficiencies of the B Lymphocyte
por: Moise, A, et al.
Publicado: (2010)

Physiology of B cells in mice with X-linked immunodeficiency. II. Influence of the thymus and mature T cells on B cell differentiation
Publicado: (1984)

Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening
por: Verstegen, Ruud H. J., et al.
Publicado: (2019)

Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin
por: Huang, Lu, et al.
Publicado: (2017)

Novel Discoveries in Immune Dysregulation in Inborn Errors of Immunity
por: Ren, Anwen, et al.
Publicado: (2021)

Development of Ly-1+ B cells in immunodeficient CBA/N mice
Publicado: (1987)

Mutations in topoisomerase IIβ result in a B cell immunodeficiency
por: Broderick, Lori, et al.
Publicado: (2019)

B Cell Dysregulation in Common Variable Immunodeficiency Interstitial Lung Disease
por: Matson, Erik M., et al.
Publicado: (2021)

SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells
por: Truong, Xuan T., et al.
Publicado: (2022)

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells
Publicado: (1990)

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells
por: MacLean, Glenn A., et al.
Publicado: (2018)

CD23 can negatively regulate B-cell receptor signaling
por: Liu, Chaohong, et al.
Publicado: (2016)

Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients
por: Zhao, Chong, et al.
Publicado: (2021)

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency
por: Walter, Jolan E., et al.
Publicado: (2010)

Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish
por: Chi, Yali, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u2nnvdi86e3udof00gn7ijn55o