The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review

[Image: see text] Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB ex...

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Autores principales: Bullert, Amanda J., Doorn, Jonathan A., Stevens, Hanna E., Lehmler, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456429/
https://www.ncbi.nlm.nih.gov/pubmed/34491731
http://dx.doi.org/10.1021/acs.chemrestox.1c00226
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author Bullert, Amanda J.
Doorn, Jonathan A.
Stevens, Hanna E.
Lehmler, Hans-Joachim
author_facet Bullert, Amanda J.
Doorn, Jonathan A.
Stevens, Hanna E.
Lehmler, Hans-Joachim
author_sort Bullert, Amanda J.
collection PubMed
description [Image: see text] Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.
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spelling pubmed-84564292021-09-23 The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review Bullert, Amanda J. Doorn, Jonathan A. Stevens, Hanna E. Lehmler, Hans-Joachim Chem Res Toxicol [Image: see text] Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system. American Chemical Society 2021-09-07 2021-09-20 /pmc/articles/PMC8456429/ /pubmed/34491731 http://dx.doi.org/10.1021/acs.chemrestox.1c00226 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Bullert, Amanda J.
Doorn, Jonathan A.
Stevens, Hanna E.
Lehmler, Hans-Joachim
The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title_full The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title_fullStr The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title_full_unstemmed The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title_short The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
title_sort effects of polychlorinated biphenyl exposure during adolescence on the nervous system: a comprehensive review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456429/
https://www.ncbi.nlm.nih.gov/pubmed/34491731
http://dx.doi.org/10.1021/acs.chemrestox.1c00226
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