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Association between obesity and iron deficiency (Review)

Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different ag...

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Autores principales: Alshwaiyat, Naseem Mohammad, Ahmad, Aryati, Wan Hassan, Wan Mohd Razin, Al-Jamal, Hamid Ali Nagi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456489/
https://www.ncbi.nlm.nih.gov/pubmed/34594405
http://dx.doi.org/10.3892/etm.2021.10703
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author Alshwaiyat, Naseem Mohammad
Ahmad, Aryati
Wan Hassan, Wan Mohd Razin
Al-Jamal, Hamid Ali Nagi
author_facet Alshwaiyat, Naseem Mohammad
Ahmad, Aryati
Wan Hassan, Wan Mohd Razin
Al-Jamal, Hamid Ali Nagi
author_sort Alshwaiyat, Naseem Mohammad
collection PubMed
description Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different age and sex categories suggests an association between obesity and iron status. Obesity may disrupt iron homeostasis, resulting in iron deficiency anemia. The association between obesity and iron deficiency may be due to increased hepcidin levels mediated by chronic inflammation. Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption. Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption. However, further randomized controlled trials are required to confirm this effect.
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spelling pubmed-84564892021-09-29 Association between obesity and iron deficiency (Review) Alshwaiyat, Naseem Mohammad Ahmad, Aryati Wan Hassan, Wan Mohd Razin Al-Jamal, Hamid Ali Nagi Exp Ther Med Review Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different age and sex categories suggests an association between obesity and iron status. Obesity may disrupt iron homeostasis, resulting in iron deficiency anemia. The association between obesity and iron deficiency may be due to increased hepcidin levels mediated by chronic inflammation. Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption. Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption. However, further randomized controlled trials are required to confirm this effect. D.A. Spandidos 2021-11 2021-09-07 /pmc/articles/PMC8456489/ /pubmed/34594405 http://dx.doi.org/10.3892/etm.2021.10703 Text en Copyright: © Alshwaiyat et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Alshwaiyat, Naseem Mohammad
Ahmad, Aryati
Wan Hassan, Wan Mohd Razin
Al-Jamal, Hamid Ali Nagi
Association between obesity and iron deficiency (Review)
title Association between obesity and iron deficiency (Review)
title_full Association between obesity and iron deficiency (Review)
title_fullStr Association between obesity and iron deficiency (Review)
title_full_unstemmed Association between obesity and iron deficiency (Review)
title_short Association between obesity and iron deficiency (Review)
title_sort association between obesity and iron deficiency (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456489/
https://www.ncbi.nlm.nih.gov/pubmed/34594405
http://dx.doi.org/10.3892/etm.2021.10703
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