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TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA levels. During the interspike intervals, subthreshold slow depolarization underlies autonomous pacemaking and determines its rate. However, the ion channels that determine slow depolarization are unknown. Here we show...

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Detalles Bibliográficos
Autores principales: Um, Ki Bum, Hahn, Suyun, Kim, So Woon, Lee, Yoon Je, Birnbaumer, Lutz, Kim, Hyun Jin, Park, Myoung Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456572/
https://www.ncbi.nlm.nih.gov/pubmed/34409942
http://dx.doi.org/10.7554/eLife.70920