Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

BACKGROUND: Intra-tumor heterogeneity (ITH) encompasses cellular differences in tumors and is related to clinical outcomes such as drug resistance. However, little is known about the dynamics of ITH, owing to the lack of time-series analysis at the single-cell level. Mouse models that recapitulate c...

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Detalles Bibliográficos
Autores principales: Ono, Hanako, Arai, Yasuhito, Furukawa, Eisaku, Narushima, Daichi, Matsuura, Tetsuya, Nakamura, Hiromi, Shiokawa, Daisuke, Nagai, Momoko, Imai, Toshio, Mimori, Koshi, Okamoto, Koji, Hippo, Yoshitaka, Shibata, Tatsuhiro, Kato, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456589/
https://www.ncbi.nlm.nih.gov/pubmed/34548081
http://dx.doi.org/10.1186/s12915-021-01147-5

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