Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats

BACKGROUND: Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced lung injury (VILI). Piezo1 is a key element of the mechanotransduction process and can transduce mechanical signals into biological signals by mediating Ca(2+) influx, which in turn regulates c...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Jiang, Lulu, Huang, Tianfeng, Lu, Dahao, Song, Yue, Wang, Lihui, Gao, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456630/
https://www.ncbi.nlm.nih.gov/pubmed/34548087
http://dx.doi.org/10.1186/s12931-021-01844-3

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