Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum

We read with great interest the article by Yin et al. (Parasit Vectors 14:238, 2021). The authors found that Cryptosporidium infection induced significantly aberrant expression of circular RNA profiles in HCT-8 cells, a finding which has far-reaching implications. However, due to the high number of...

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Autores principales: Wang, Yuqing, Zhao, Heng, Zhang, Yanan, Yan, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456637/
https://www.ncbi.nlm.nih.gov/pubmed/34548105
http://dx.doi.org/10.1186/s13071-021-04957-2
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author Wang, Yuqing
Zhao, Heng
Zhang, Yanan
Yan, Lei
author_facet Wang, Yuqing
Zhao, Heng
Zhang, Yanan
Yan, Lei
author_sort Wang, Yuqing
collection PubMed
description We read with great interest the article by Yin et al. (Parasit Vectors 14:238, 2021). The authors found that Cryptosporidium infection induced significantly aberrant expression of circular RNA profiles in HCT-8 cells, a finding which has far-reaching implications. However, due to the high number of false positives caused by multiple comparisons, statistical methods for microarray analysis should be carefully selected. Accurate analysis results will provide a convincing basis for subsequent experiments. In addition, we recommend several more appropriate methods in this article.
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spelling pubmed-84566372021-09-22 Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum Wang, Yuqing Zhao, Heng Zhang, Yanan Yan, Lei Parasit Vectors Letter to the Editor We read with great interest the article by Yin et al. (Parasit Vectors 14:238, 2021). The authors found that Cryptosporidium infection induced significantly aberrant expression of circular RNA profiles in HCT-8 cells, a finding which has far-reaching implications. However, due to the high number of false positives caused by multiple comparisons, statistical methods for microarray analysis should be carefully selected. Accurate analysis results will provide a convincing basis for subsequent experiments. In addition, we recommend several more appropriate methods in this article. BioMed Central 2021-09-21 /pmc/articles/PMC8456637/ /pubmed/34548105 http://dx.doi.org/10.1186/s13071-021-04957-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Wang, Yuqing
Zhao, Heng
Zhang, Yanan
Yan, Lei
Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title_full Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title_fullStr Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title_full_unstemmed Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title_short Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum
title_sort microarray analysis of circular rnas in hct-8 cells infected with cryptosporidium parvum
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456637/
https://www.ncbi.nlm.nih.gov/pubmed/34548105
http://dx.doi.org/10.1186/s13071-021-04957-2
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