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Patterns and grades of presentation of colon cancer in Northern Saudi Arabia
INTRODUCTION: The primary concern related to colon cancer in Saudi Arabia is the presentation of many patients with advanced disease stages. AIM: To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia. MATERIAL AND METHODS: Retrieved data and tissue blocks related...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456767/ https://www.ncbi.nlm.nih.gov/pubmed/34584586 http://dx.doi.org/10.5114/pg.2021.104168 |
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author | Alharbi, Saleh H. Alshammari, Khalil I. Alanazi, Khulaif Khalaf Ahmed, Hussain Gadelkarim |
author_facet | Alharbi, Saleh H. Alshammari, Khalil I. Alanazi, Khulaif Khalaf Ahmed, Hussain Gadelkarim |
author_sort | Alharbi, Saleh H. |
collection | PubMed |
description | INTRODUCTION: The primary concern related to colon cancer in Saudi Arabia is the presentation of many patients with advanced disease stages. AIM: To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia. MATERIAL AND METHODS: Retrieved data and tissue blocks related to 50 colorectal patients from King Khalid Hospital, Hai’l province, Northern Saudi Arabia were used. The sample represented all available colorectal specimens (full coverage of cancer cases within 10 years). The retrieved data included a full histopathology report, gender, and age. All tissues were retrieved in the form of formalin-fixed paraffin wax processed blocks. The tissues were found to be obtained in the form of colonoscopy or/and biopsy. RESULTS: The diagnosed colon cancers included conventional adenocarcinoma 36 (72%), mucinous adenocarcinoma 4 (8%), carcinoma-in-situ 4 (8%), and invasive adenocarcinoma 6 (12%). Moderately differentiated and poorly differentiated stages were confirmed in 46 (92%) and 4 (8%), respectively. CONCLUSIONS: Conventional adenocarcinoma is the most common presenting colon cancer at and relatively younger age. Mucinous adenocarcinoma is frequently presented in female patients of a somewhat more youthful generation. Most patients are diagnosed with moderately differentiated adenocarcinoma, followed by poorly differentiated adenocarcinoma. The findings necessitate the urgent intervention of national policies for early detection by implementing sustainable screening programs. |
format | Online Article Text |
id | pubmed-8456767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-84567672021-09-27 Patterns and grades of presentation of colon cancer in Northern Saudi Arabia Alharbi, Saleh H. Alshammari, Khalil I. Alanazi, Khulaif Khalaf Ahmed, Hussain Gadelkarim Prz Gastroenterol Original Paper INTRODUCTION: The primary concern related to colon cancer in Saudi Arabia is the presentation of many patients with advanced disease stages. AIM: To determine the patterns and grades of colon cancer presentation in Northern Saudi Arabia. MATERIAL AND METHODS: Retrieved data and tissue blocks related to 50 colorectal patients from King Khalid Hospital, Hai’l province, Northern Saudi Arabia were used. The sample represented all available colorectal specimens (full coverage of cancer cases within 10 years). The retrieved data included a full histopathology report, gender, and age. All tissues were retrieved in the form of formalin-fixed paraffin wax processed blocks. The tissues were found to be obtained in the form of colonoscopy or/and biopsy. RESULTS: The diagnosed colon cancers included conventional adenocarcinoma 36 (72%), mucinous adenocarcinoma 4 (8%), carcinoma-in-situ 4 (8%), and invasive adenocarcinoma 6 (12%). Moderately differentiated and poorly differentiated stages were confirmed in 46 (92%) and 4 (8%), respectively. CONCLUSIONS: Conventional adenocarcinoma is the most common presenting colon cancer at and relatively younger age. Mucinous adenocarcinoma is frequently presented in female patients of a somewhat more youthful generation. Most patients are diagnosed with moderately differentiated adenocarcinoma, followed by poorly differentiated adenocarcinoma. The findings necessitate the urgent intervention of national policies for early detection by implementing sustainable screening programs. Termedia Publishing House 2021-03-05 2021 /pmc/articles/PMC8456767/ /pubmed/34584586 http://dx.doi.org/10.5114/pg.2021.104168 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Alharbi, Saleh H. Alshammari, Khalil I. Alanazi, Khulaif Khalaf Ahmed, Hussain Gadelkarim Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title | Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title_full | Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title_fullStr | Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title_full_unstemmed | Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title_short | Patterns and grades of presentation of colon cancer in Northern Saudi Arabia |
title_sort | patterns and grades of presentation of colon cancer in northern saudi arabia |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456767/ https://www.ncbi.nlm.nih.gov/pubmed/34584586 http://dx.doi.org/10.5114/pg.2021.104168 |
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