Combining High‐Throughput Synthesis and High‐Throughput Protein Crystallography for Accelerated Hit Identification

Protein crystallography (PX) is widely used to drive advanced stages of drug optimization or to discover medicinal chemistry starting points by fragment soaking. However, recent progress in PX could allow for a more integrated role into early drug discovery. Here, we demonstrate for the first time t...

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Detalles Bibliográficos
Autores principales: Sutanto, Fandi, Shaabani, Shabnam, Oerlemans, Rick, Eris, Deniz, Patil, Pravin, Hadian, Mojgan, Wang, Meitian, Sharpe, May Elizabeth, Groves, Matthew R., Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456925/
https://www.ncbi.nlm.nih.gov/pubmed/34097796
http://dx.doi.org/10.1002/anie.202105584

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