Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes

A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp(3))−Si bond can be formed starting from two electrophilic reactan...

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Detalles Bibliográficos
Autores principales: Zhang, Liangliang, Oestreich, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456968/
https://www.ncbi.nlm.nih.gov/pubmed/34213049
http://dx.doi.org/10.1002/anie.202107492
Descripción
Sumario:A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp(3))−Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.

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