Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes

A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp(3))−Si bond can be formed starting from two electrophilic reactan...

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Detalles Bibliográficos
Autores principales: Zhang, Liangliang, Oestreich, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456968/
https://www.ncbi.nlm.nih.gov/pubmed/34213049
http://dx.doi.org/10.1002/anie.202107492
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author Zhang, Liangliang
Oestreich, Martin
author_facet Zhang, Liangliang
Oestreich, Martin
author_sort Zhang, Liangliang
collection PubMed
description A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp(3))−Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.
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spelling pubmed-84569682021-09-27 Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes Zhang, Liangliang Oestreich, Martin Angew Chem Int Ed Engl Communications A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp(3))−Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa. John Wiley and Sons Inc. 2021-07-16 2021-08-16 /pmc/articles/PMC8456968/ /pubmed/34213049 http://dx.doi.org/10.1002/anie.202107492 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Zhang, Liangliang
Oestreich, Martin
Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title_full Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title_fullStr Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title_full_unstemmed Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title_short Nickel‐Catalyzed, Reductive C(sp(3))−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes
title_sort nickel‐catalyzed, reductive c(sp(3))−si cross‐coupling of α‐cyano alkyl electrophiles and chlorosilanes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456968/
https://www.ncbi.nlm.nih.gov/pubmed/34213049
http://dx.doi.org/10.1002/anie.202107492
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AT oestreichmartin nickelcatalyzedreductivecsp3sicrosscouplingofacyanoalkylelectrophilesandchlorosilanes

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