Mistranslation can promote the exploration of alternative evolutionary trajectories in enzyme evolution

Darwinian evolution preferentially follows mutational pathways whose individual steps increase fitness. Alternative pathways with mutational steps that do not increase fitness are less accessible. Here, we show that mistranslation, the erroneous incorporation of amino acids into nascent proteins, ca...

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Detalles Bibliográficos
Autores principales: Zheng, Jia, Bratulic, Sinisa, Lischer, Heidi E. L., Wagner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457080/
https://www.ncbi.nlm.nih.gov/pubmed/34145657
http://dx.doi.org/10.1111/jeb.13892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457080/
https://www.ncbi.nlm.nih.gov/pubmed/34145657
http://dx.doi.org/10.1111/jeb.13892

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