Enabling Cysteine‐Free Native Chemical Ligation at Challenging Junctions with a Ligation Auxiliary Capable of Base Catalysis

Ligation auxiliaries are used in chemical protein synthesis to extend the scope of native chemical ligation (NCL) beyond cysteine. However, auxiliary‐mediated ligations at sterically demanding junctions have been difficult. Often the thioester intermediate formed in the thiol exchange step of NCL ac...

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Detalles Bibliográficos
Autores principales: Fuchs, Olaf, Trunschke, Sebastian, Hanebrink, Hendrik, Reimann, Marc, Seitz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457107/
https://www.ncbi.nlm.nih.gov/pubmed/34165893
http://dx.doi.org/10.1002/anie.202107158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457107/
https://www.ncbi.nlm.nih.gov/pubmed/34165893
http://dx.doi.org/10.1002/anie.202107158

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