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Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports

OBJECTIVE/HYPOTHESIS: To examine the clinical features of benign intratracheal thyroid (ITT) and their management strategies and outcomes. STUDY DESIGN: Case series study. METHODS: This systemic review was conducted in two international academic centers. This review includes 43 patients: one new cas...

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Autores principales: Ma, Hongzhi, Brooks, Jennifer A., Iwata, Ayaka J., Li, Pingdong, Zhong, Qi, Fang, Jugao, Randolph, Gregory W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457119/
https://www.ncbi.nlm.nih.gov/pubmed/34184770
http://dx.doi.org/10.1002/lary.29678
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author Ma, Hongzhi
Brooks, Jennifer A.
Iwata, Ayaka J.
Li, Pingdong
Zhong, Qi
Fang, Jugao
Randolph, Gregory W.
author_facet Ma, Hongzhi
Brooks, Jennifer A.
Iwata, Ayaka J.
Li, Pingdong
Zhong, Qi
Fang, Jugao
Randolph, Gregory W.
author_sort Ma, Hongzhi
collection PubMed
description OBJECTIVE/HYPOTHESIS: To examine the clinical features of benign intratracheal thyroid (ITT) and their management strategies and outcomes. STUDY DESIGN: Case series study. METHODS: This systemic review was conducted in two international academic centers. This review includes 43 patients: one new case from the Massachusetts Eye and Ear Infirmary, four new cases from Beijing Tongren Hospital, and 38 previously published cases. We analyzed these 43 cases and summarized the patients' epidemiological data, clinical features, and treatment regimens. RESULTS: ITTs were less common in men than in women (male:female ratio of 3:10). ITT was observed in patients as young as neonates and as old as 85 years. Orthotopic thyroid nodules were present in 55.8% of the patients with ITT. Malignancy was incidentally found in 4.6% of all ITTs. Imaging examinations showed that the ITTs were typically attached to the posterolateral/lateral tracheal wall of the first, second, or third tracheal rings. Tissue attachment between the ITT and normal thyroid lobes was seen in 59.5% of the patients. Thirty‐seven patients underwent surgery: 30 underwent open surgery, and seven underwent endoscopic debulking resections. One neonate received thyroid suppression therapy. One patient with ITT and papillary thyroid cancer was treated with radiotherapy and ultimately died after recurrence. CONCLUSIONS: Surgical resection is an effective treatment for benign ITT. We hypothesized that abnormalities during the embryonic development of Berry's ligament might play a role in ITT pathogenesis. LEVEL OF EVIDENCE: NA Laryngoscope, 131:E2609–E2617, 2021
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spelling pubmed-84571192021-09-27 Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports Ma, Hongzhi Brooks, Jennifer A. Iwata, Ayaka J. Li, Pingdong Zhong, Qi Fang, Jugao Randolph, Gregory W. Laryngoscope Thyroid, Parathyroid, and Endocrine OBJECTIVE/HYPOTHESIS: To examine the clinical features of benign intratracheal thyroid (ITT) and their management strategies and outcomes. STUDY DESIGN: Case series study. METHODS: This systemic review was conducted in two international academic centers. This review includes 43 patients: one new case from the Massachusetts Eye and Ear Infirmary, four new cases from Beijing Tongren Hospital, and 38 previously published cases. We analyzed these 43 cases and summarized the patients' epidemiological data, clinical features, and treatment regimens. RESULTS: ITTs were less common in men than in women (male:female ratio of 3:10). ITT was observed in patients as young as neonates and as old as 85 years. Orthotopic thyroid nodules were present in 55.8% of the patients with ITT. Malignancy was incidentally found in 4.6% of all ITTs. Imaging examinations showed that the ITTs were typically attached to the posterolateral/lateral tracheal wall of the first, second, or third tracheal rings. Tissue attachment between the ITT and normal thyroid lobes was seen in 59.5% of the patients. Thirty‐seven patients underwent surgery: 30 underwent open surgery, and seven underwent endoscopic debulking resections. One neonate received thyroid suppression therapy. One patient with ITT and papillary thyroid cancer was treated with radiotherapy and ultimately died after recurrence. CONCLUSIONS: Surgical resection is an effective treatment for benign ITT. We hypothesized that abnormalities during the embryonic development of Berry's ligament might play a role in ITT pathogenesis. LEVEL OF EVIDENCE: NA Laryngoscope, 131:E2609–E2617, 2021 John Wiley & Sons, Inc. 2021-06-29 2021-09 /pmc/articles/PMC8457119/ /pubmed/34184770 http://dx.doi.org/10.1002/lary.29678 Text en © 2021 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Thyroid, Parathyroid, and Endocrine
Ma, Hongzhi
Brooks, Jennifer A.
Iwata, Ayaka J.
Li, Pingdong
Zhong, Qi
Fang, Jugao
Randolph, Gregory W.
Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title_full Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title_fullStr Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title_full_unstemmed Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title_short Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports
title_sort benign intratracheal thyroid: a systematic review of 43 cases with five new case reports
topic Thyroid, Parathyroid, and Endocrine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457119/
https://www.ncbi.nlm.nih.gov/pubmed/34184770
http://dx.doi.org/10.1002/lary.29678
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