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General α‐Amino 1,3,4‐Oxadiazole Synthesis via Late‐Stage Reductive Functionalization of Tertiary Amides and Lactams
An iridium‐catalyzed reductive three‐component coupling reaction for the synthesis of medicinally relevant α‐amino 1,3,4‐oxadiazoles from abundant tertiary amides or lactams, carboxylic acids, and (N‐isocyanimino) triphenylphosphorane, is described. Proceeding under mild conditions using (<1 mol ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457168/ https://www.ncbi.nlm.nih.gov/pubmed/34191400 http://dx.doi.org/10.1002/anie.202107536 |