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Mechanically Interlocked Chiral Self‐Templated [2]Catenanes from 2,6‐Bis(1,2,3‐triazol‐4‐yl)pyridine (btp) Ligands

We report the efficient self‐templated formation of optically active 2,6‐bis(1,2,3‐triazol‐4‐yl)pyridine (btp) derived homocircuit [2]catenane enantiomers. This represents the first example of the enantiopure formation of chiral btp homocircuit [2]catenanes from starting materials consisting of a cl...

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Detalles Bibliográficos
Autores principales: McCarney, Eoin P., Lovitt, June I., Gunnlaugsson, Thorfinnur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457180/
https://www.ncbi.nlm.nih.gov/pubmed/34106499
http://dx.doi.org/10.1002/chem.202101773
Descripción
Sumario:We report the efficient self‐templated formation of optically active 2,6‐bis(1,2,3‐triazol‐4‐yl)pyridine (btp) derived homocircuit [2]catenane enantiomers. This represents the first example of the enantiopure formation of chiral btp homocircuit [2]catenanes from starting materials consisting of a classical chiral element; X‐ray diffraction crystallography enabled the structural characterization of the [2]catenane. The self‐assembly reaction was monitored closely in solution facilitating the characterization of the pseudo‐rotaxane reaction intermediate prior to mechanically interlocking the pre‐organised system via ring‐closing metathesis.