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A direct-to-biology high-throughput chemistry approach to reactive fragment screening

Methods for rapid identification of chemical tools are essential for the validation of emerging targets and to provide medicinal chemistry starting points for the development of new medicines. Here, we report a screening platform that combines ‘direct-to-biology’ high-throughput chemistry (D2B-HTC)...

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Detalles Bibliográficos
Autores principales: Thomas, Ross P., Heap, Rachel E., Zappacosta, Francesca, Grant, Emma K., Pogány, Peter, Besley, Stephen, Fallon, David J., Hann, Michael M., House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457371/
https://www.ncbi.nlm.nih.gov/pubmed/34667575
http://dx.doi.org/10.1039/d1sc03551g

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