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A direct-to-biology high-throughput chemistry approach to reactive fragment screening
Methods for rapid identification of chemical tools are essential for the validation of emerging targets and to provide medicinal chemistry starting points for the development of new medicines. Here, we report a screening platform that combines ‘direct-to-biology’ high-throughput chemistry (D2B-HTC)...
Autores principales: | Thomas, Ross P., Heap, Rachel E., Zappacosta, Francesca, Grant, Emma K., Pogány, Peter, Besley, Stephen, Fallon, David J., Hann, Michael M., House, David, Tomkinson, Nicholas C. O., Bush, Jacob T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457371/ https://www.ncbi.nlm.nih.gov/pubmed/34667575 http://dx.doi.org/10.1039/d1sc03551g |
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