A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Multidrug-resistant Gram-negative bacteria represent a major medical challenge worldwide. New antibiotics are desperately required with ‘old’ polymyxins often being the only available therapeutic option. Here, we systematically investigated the structure–activity relationship (SAR) of polymyxins usi...

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Detalles Bibliográficos
Autores principales: Jiang, Xukai, Patil, Nitin A., Azad, Mohammad A. K., Wickremasinghe, Hasini, Yu, Heidi, Zhao, Jinxin, Zhang, Xinru, Li, Mengyao, Gong, Bin, Wan, Lin, Ma, Wendong, Thompson, Philip E., Yang, Kai, Yuan, Bing, Schreiber, Falk, Wang, Lushan, Velkov, Tony, Roberts, Kade D., Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457388/
https://www.ncbi.nlm.nih.gov/pubmed/34667587
http://dx.doi.org/10.1039/d1sc03460j

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