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Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia
BACKGROUND: To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants. METHODS: Prospective study involving 294 very preterm infants (median [IQR] gestati...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457497/ https://www.ncbi.nlm.nih.gov/pubmed/34550991 http://dx.doi.org/10.1371/journal.pone.0257571 |
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author | Neumann, Roland P. Schulzke, Sven M. Pohl, Christian Wellmann, Sven Metze, Boris Burdensky, Ann-Katrin Boos, Vinzenz Barikbin, Payman Bührer, Christoph Czernik, Christoph |
author_facet | Neumann, Roland P. Schulzke, Sven M. Pohl, Christian Wellmann, Sven Metze, Boris Burdensky, Ann-Katrin Boos, Vinzenz Barikbin, Payman Bührer, Christoph Czernik, Christoph |
author_sort | Neumann, Roland P. |
collection | PubMed |
description | BACKGROUND: To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants. METHODS: Prospective study involving 294 very preterm infants (median [IQR] gestational age 28.4 [26.4–30.4] weeks, birth weight 1065 [800–1380] g), of whom 57 developed BPD (oxygen supplementation at 36 weeks postmenstrual age) and 10 died. Tricuspid annular plane systolic excursion (TAPSE), right ventricular index of myocardial performance (RIMP), plasma concentrations of mid-regional pro-atrial natriuretic peptide (MR-proANP) and C-terminal pro-endothelin-1 (CT-proET1) were measured on day 7 of life. RESULTS: RIMP was significantly increased (median [IQR] 0.3 [0.23–0.38] vs 0.22 [0.15–0.29]), TAPSE decreased (median [IQR] 5.0 [5.0–6.0] vs 6.0 [5.4–7.0] mm), MR-proANP increased (median [IQR] 784 [540–936] vs 353 [247–625] pmol/L), and CT-proET1 increased (median [IQR] 249 [190–345] vs 199 [158–284] pmol/L) in infants who developed BPD or died, as compared to controls. All variables showed significant but weak correlations with each other (r(S) -0.182 to 0.359) and predicted BPD/death with similar accuracy (areas under receiver operator characteristic curves 0.62 to 0.77). Multiple regression revealed only RIMP and birth weight as independent predictors of BPD or death. CONCLUSIONS: Vasoactive peptide concentrations and echocardiographic assessment employing standardized measures, notably RIMP, on day 7 of life are useful to identify preterm infants at increased risk for BPD or death. |
format | Online Article Text |
id | pubmed-8457497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-84574972021-09-23 Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia Neumann, Roland P. Schulzke, Sven M. Pohl, Christian Wellmann, Sven Metze, Boris Burdensky, Ann-Katrin Boos, Vinzenz Barikbin, Payman Bührer, Christoph Czernik, Christoph PLoS One Research Article BACKGROUND: To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants. METHODS: Prospective study involving 294 very preterm infants (median [IQR] gestational age 28.4 [26.4–30.4] weeks, birth weight 1065 [800–1380] g), of whom 57 developed BPD (oxygen supplementation at 36 weeks postmenstrual age) and 10 died. Tricuspid annular plane systolic excursion (TAPSE), right ventricular index of myocardial performance (RIMP), plasma concentrations of mid-regional pro-atrial natriuretic peptide (MR-proANP) and C-terminal pro-endothelin-1 (CT-proET1) were measured on day 7 of life. RESULTS: RIMP was significantly increased (median [IQR] 0.3 [0.23–0.38] vs 0.22 [0.15–0.29]), TAPSE decreased (median [IQR] 5.0 [5.0–6.0] vs 6.0 [5.4–7.0] mm), MR-proANP increased (median [IQR] 784 [540–936] vs 353 [247–625] pmol/L), and CT-proET1 increased (median [IQR] 249 [190–345] vs 199 [158–284] pmol/L) in infants who developed BPD or died, as compared to controls. All variables showed significant but weak correlations with each other (r(S) -0.182 to 0.359) and predicted BPD/death with similar accuracy (areas under receiver operator characteristic curves 0.62 to 0.77). Multiple regression revealed only RIMP and birth weight as independent predictors of BPD or death. CONCLUSIONS: Vasoactive peptide concentrations and echocardiographic assessment employing standardized measures, notably RIMP, on day 7 of life are useful to identify preterm infants at increased risk for BPD or death. Public Library of Science 2021-09-22 /pmc/articles/PMC8457497/ /pubmed/34550991 http://dx.doi.org/10.1371/journal.pone.0257571 Text en © 2021 Neumann et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Neumann, Roland P. Schulzke, Sven M. Pohl, Christian Wellmann, Sven Metze, Boris Burdensky, Ann-Katrin Boos, Vinzenz Barikbin, Payman Bührer, Christoph Czernik, Christoph Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title | Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title_full | Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title_fullStr | Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title_full_unstemmed | Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title_short | Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
title_sort | right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457497/ https://www.ncbi.nlm.nih.gov/pubmed/34550991 http://dx.doi.org/10.1371/journal.pone.0257571 |
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