Regulation and Evasion of Host Immune Response by African Swine Fever Virus

African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-s...

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Detalles Bibliográficos
Autores principales: Wu, Lei, Yang, Bincai, Yuan, Xu, Hong, Jinxuan, Peng, Min, Chen, Ji-Long, Song, Zhongbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457549/
https://www.ncbi.nlm.nih.gov/pubmed/34566910
http://dx.doi.org/10.3389/fmicb.2021.698001
Descripción
Sumario:African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.

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