Regulation and Evasion of Host Immune Response by African Swine Fever Virus

African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-s...

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Autores principales: Wu, Lei, Yang, Bincai, Yuan, Xu, Hong, Jinxuan, Peng, Min, Chen, Ji-Long, Song, Zhongbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457549/
https://www.ncbi.nlm.nih.gov/pubmed/34566910
http://dx.doi.org/10.3389/fmicb.2021.698001
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author Wu, Lei
Yang, Bincai
Yuan, Xu
Hong, Jinxuan
Peng, Min
Chen, Ji-Long
Song, Zhongbao
author_facet Wu, Lei
Yang, Bincai
Yuan, Xu
Hong, Jinxuan
Peng, Min
Chen, Ji-Long
Song, Zhongbao
author_sort Wu, Lei
collection PubMed
description African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.
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spelling pubmed-84575492021-09-23 Regulation and Evasion of Host Immune Response by African Swine Fever Virus Wu, Lei Yang, Bincai Yuan, Xu Hong, Jinxuan Peng, Min Chen, Ji-Long Song, Zhongbao Front Microbiol Microbiology African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity. Frontiers Media S.A. 2021-09-08 /pmc/articles/PMC8457549/ /pubmed/34566910 http://dx.doi.org/10.3389/fmicb.2021.698001 Text en Copyright © 2021 Wu, Yang, Yuan, Hong, Peng, Chen and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wu, Lei
Yang, Bincai
Yuan, Xu
Hong, Jinxuan
Peng, Min
Chen, Ji-Long
Song, Zhongbao
Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title_full Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title_fullStr Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title_full_unstemmed Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title_short Regulation and Evasion of Host Immune Response by African Swine Fever Virus
title_sort regulation and evasion of host immune response by african swine fever virus
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457549/
https://www.ncbi.nlm.nih.gov/pubmed/34566910
http://dx.doi.org/10.3389/fmicb.2021.698001
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