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Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study
Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psycholog...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457564/ https://www.ncbi.nlm.nih.gov/pubmed/34516404 http://dx.doi.org/10.18632/aging.203510 |
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author | Hu, Jin-Yu Shu, Hui-Ye Li, Qiu-Yu Wu, Shi-Nan Liang, Rong-Bin Ge, Qian-Min Zhang, Li-Juan Pan, Yi-Cong Shao, Yi |
author_facet | Hu, Jin-Yu Shu, Hui-Ye Li, Qiu-Yu Wu, Shi-Nan Liang, Rong-Bin Ge, Qian-Min Zhang, Li-Juan Pan, Yi-Cong Shao, Yi |
author_sort | Hu, Jin-Yu |
collection | PubMed |
description | Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psychological changes. Methods: Thirty-one patients with hypertensive retinopathy (HR) (16 men and 15 women) and 31 healthy controls (HCs; 16 men and 15 women) matched for age, sex, and weight were enrolled in the research. The changes in mean ALFF values could reflect brain activity between HR patients and HCs. We used the independent samples t-test to evaluate different demographic and general information between the two groups. Two-sample t-test was used to detect differences of mean ALFF values in the brain region between the two groups using the same software. Results: The ALFF values in the brain areas of HR and HCs were different. HR patients had lower ALFF value in the left medial superior frontal gyrus and left middle frontal gyrus than the HCs. The higher ALFF values were found in the cerebellum (left inferior and right superior lobes, vermis) and left inferior temporal gyrus of the HR patients than the controls. Conclusion: Our findings showed fluctuations in ALFF values in the HR patients’ brain regions. ALFF values reflect over or reduced activity in brain regions. Abnormal ALFF values in these brain areas can predict early HR development, preventing the malignant transformation of hypertensive microangiopathy. |
format | Online Article Text |
id | pubmed-8457564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-84575642021-09-23 Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study Hu, Jin-Yu Shu, Hui-Ye Li, Qiu-Yu Wu, Shi-Nan Liang, Rong-Bin Ge, Qian-Min Zhang, Li-Juan Pan, Yi-Cong Shao, Yi Aging (Albany NY) Research Paper Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psychological changes. Methods: Thirty-one patients with hypertensive retinopathy (HR) (16 men and 15 women) and 31 healthy controls (HCs; 16 men and 15 women) matched for age, sex, and weight were enrolled in the research. The changes in mean ALFF values could reflect brain activity between HR patients and HCs. We used the independent samples t-test to evaluate different demographic and general information between the two groups. Two-sample t-test was used to detect differences of mean ALFF values in the brain region between the two groups using the same software. Results: The ALFF values in the brain areas of HR and HCs were different. HR patients had lower ALFF value in the left medial superior frontal gyrus and left middle frontal gyrus than the HCs. The higher ALFF values were found in the cerebellum (left inferior and right superior lobes, vermis) and left inferior temporal gyrus of the HR patients than the controls. Conclusion: Our findings showed fluctuations in ALFF values in the HR patients’ brain regions. ALFF values reflect over or reduced activity in brain regions. Abnormal ALFF values in these brain areas can predict early HR development, preventing the malignant transformation of hypertensive microangiopathy. Impact Journals 2021-09-13 /pmc/articles/PMC8457564/ /pubmed/34516404 http://dx.doi.org/10.18632/aging.203510 Text en Copyright: © 2021 Hu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hu, Jin-Yu Shu, Hui-Ye Li, Qiu-Yu Wu, Shi-Nan Liang, Rong-Bin Ge, Qian-Min Zhang, Li-Juan Pan, Yi-Cong Shao, Yi Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title | Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title_full | Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title_fullStr | Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title_full_unstemmed | Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title_short | Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study |
title_sort | alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fmri study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457564/ https://www.ncbi.nlm.nih.gov/pubmed/34516404 http://dx.doi.org/10.18632/aging.203510 |
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