Cargando…

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen, led to the hardest health-socio-economic disaster in the last century. Despite the tremendous scientific efforts, mainly focused on the development of vaccines, identification of potent and efficient anti-SARS-CoV-2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Sarno, Veronica, Lauro, Gianluigi, Musella, Simona, Ciaglia, Tania, Vestuto, Vincenzo, Sala, Marina, Scala, Maria Carmina, Smaldone, Gerardina, Di Matteo, Francesca, Novi, Sara, Tecce, Mario Felice, Moltedo, Ornella, Bifulco, Giuseppe, Campiglia, Pietro, Gomez-Monterrey, Isabel M., Snoeck, Robert, Andrei, Graciela, Ostacolo, Carmine, Bertamino, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457654/ https://www.ncbi.nlm.nih.gov/pubmed/34571172 http://dx.doi.org/10.1016/j.ejmech.2021.113863

Ejemplares similares

New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors?
por: Vestuto, Vincenzo, et al.
Publicado: (2022)

Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities
por: Bertamino, Alessia, et al.
Publicado: (2020)

An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source
por: Ostacolo, Carmine, et al.
Publicado: (2019)

In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents
por: Di Micco, Simone, et al.
Publicado: (2022)

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor
por: Musella, Simona, et al.
Publicado: (2016)

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization
por: Cerqua, Ida, et al.
Publicado: (2022)

Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
por: Novi, Sara, et al.
Publicado: (2023)

Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis
por: Musella, Simona, et al.
Publicado: (2023)

Therapeutic potential of TRPM8 antagonists in prostate cancer
por: Di Donato, Marzia, et al.
Publicado: (2021)

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
por: Musella, Simona, et al.
Publicado: (2022)

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications
por: Ciaglia, Tania, et al.
Publicado: (2023)

In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening
por: Iraci, Nunzio, et al.
Publicado: (2022)

Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors
por: Scala, Maria Carmina, et al.
Publicado: (2017)

Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies
por: Scala, Maria Carmina, et al.
Publicado: (2021)

Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation
por: Di Micco, Simone, et al.
Publicado: (2021)

Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2
por: Di Micco, Simone, et al.
Publicado: (2022)

Polyphenolic Extract from Tarocco (Citrus sinensis L. Osbeck) Clone “Lempso” Exerts Anti-Inflammatory and Antioxidant Effects via NF-kB and Nrf-2 Activation in Murine Macrophages
por: Pepe, Giacomo, et al.
Publicado: (2018)

Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides
por: Scala, Maria Carmina, et al.
Publicado: (2021)

Corrigendum: Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides
por: Scala, Maria Carmina, et al.
Publicado: (2022)

Characterization of New TRPM8 Modulators in Pain Perception
por: De Caro, Carmen, et al.
Publicado: (2019)

Synthesis and Ex Vivo Trans-Corneal Permeation of Penetratin Analogues as Ophthalmic Carriers: Preliminary Results
por: Pescina, Silvia, et al.
Publicado: (2020)

Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK
por: Vestuto, Vincenzo, et al.
Publicado: (2022)

β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation
por: Pepe, Giacomo, et al.
Publicado: (2019)

Antioxidant Properties of Buffalo-Milk Dairy Products: A β-Lg Peptide Released after Gastrointestinal Digestion of Buffalo Ricotta Cheese Reduces Oxidative Stress in Intestinal Epithelial Cells
por: Basilicata, Manuela Giovanna, et al.
Publicado: (2018)

In silico Analysis Revealed Potential Anti-SARS-CoV-2 Main Protease Activity by the Zonulin Inhibitor Larazotide Acetate
por: Di Micco, Simone, et al.
Publicado: (2021)

A Novel Vasoactive Peptide “PG1” from Buffalo Ice-Cream Protects from Angiotensin-Evoked High Blood Pressure
por: Carrizzo, Albino, et al.
Publicado: (2021)

Fast Profiling of Natural Pigments in Different Spirulina (Arthrospira platensis) Dietary Supplements by DI-FT-ICR and Evaluation of their Antioxidant Potential by Pre-Column DPPH-UHPLC Assay
por: Sommella, Eduardo, et al.
Publicado: (2018)

Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells
por: Basilicata, Manuela Giovanna, et al.
Publicado: (2019)

Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
por: Vernieri, Ermelinda, et al.
Publicado: (2013)

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
por: Di Micco, Simone, et al.
Publicado: (2022)

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design
por: Aquino, Giovanna, et al.
Publicado: (2023)

Potential Role of Natural Antioxidant Products in Oncological Diseases
por: Marino, Pasquale, et al.
Publicado: (2023)

Myogenesis in C2C12 Cells Requires Phosphorylation of ATF6α by p38 MAPK
por: Pagliara, Valentina, et al.
Publicado: (2023)

The Longevity-Associated Variant of BPIFB4 Reduces Senescence in Glioma Cells and in Patients’ Lymphocytes Favoring Chemotherapy Efficacy
por: Puca, Annibale Alessandro, et al.
Publicado: (2022)

Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology?
por: Quagliariello, Vincenzo, et al.
Publicado: (2022)

Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors
por: Giustiniano, Mariateresa, et al.
Publicado: (2013)

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase
por: Sala, Marina, et al.
Publicado: (2016)

Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor
por: Costa, Barbara, et al.
Publicado: (2013)

Javascript: Step by Step
por: Suehring, Steve
Publicado: (2008)

New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53
por: Sorriento, D, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jv4a4fc99as2rdkt84ocs2fmf9