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Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats
Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from inna...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457830/ https://www.ncbi.nlm.nih.gov/pubmed/34468312 http://dx.doi.org/10.7554/eLife.69178 |
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author | Wang, Weisheng Schuette, Peter J La-Vu, Mimi Q Torossian, Anita Tobias, Brooke C Ceko, Marta Kragel, Philip A Reis, Fernando MCV Ji, Shiyu Sehgal, Megha Maesta-Pereira, Sandra Chakerian, Meghmik Silva, Alcino J Canteras, Newton S Wager, Tor Kao, Jonathan C Adhikari, Avishek |
author_facet | Wang, Weisheng Schuette, Peter J La-Vu, Mimi Q Torossian, Anita Tobias, Brooke C Ceko, Marta Kragel, Philip A Reis, Fernando MCV Ji, Shiyu Sehgal, Megha Maesta-Pereira, Sandra Chakerian, Meghmik Silva, Alcino J Canteras, Newton S Wager, Tor Kao, Jonathan C Adhikari, Avishek |
author_sort | Wang, Weisheng |
collection | PubMed |
description | Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from innate threats via a projection to the dorsolateral periaqueductal gray (dlPAG). We now show that in mice PMd-cck cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Intriguingly, PMd-cck and dlPAG activity in mice showed higher mutual information during exposure to innate and conditioned threats. In parallel, human functional magnetic resonance imaging data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd-dlPAG circuit as a central node, controlling escape vigor elicited by both innate and conditioned threats. |
format | Online Article Text |
id | pubmed-8457830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-84578302021-09-24 Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats Wang, Weisheng Schuette, Peter J La-Vu, Mimi Q Torossian, Anita Tobias, Brooke C Ceko, Marta Kragel, Philip A Reis, Fernando MCV Ji, Shiyu Sehgal, Megha Maesta-Pereira, Sandra Chakerian, Meghmik Silva, Alcino J Canteras, Newton S Wager, Tor Kao, Jonathan C Adhikari, Avishek eLife Neuroscience Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from innate threats via a projection to the dorsolateral periaqueductal gray (dlPAG). We now show that in mice PMd-cck cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Intriguingly, PMd-cck and dlPAG activity in mice showed higher mutual information during exposure to innate and conditioned threats. In parallel, human functional magnetic resonance imaging data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd-dlPAG circuit as a central node, controlling escape vigor elicited by both innate and conditioned threats. eLife Sciences Publications, Ltd 2021-09-01 /pmc/articles/PMC8457830/ /pubmed/34468312 http://dx.doi.org/10.7554/eLife.69178 Text en © 2021, Wang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Wang, Weisheng Schuette, Peter J La-Vu, Mimi Q Torossian, Anita Tobias, Brooke C Ceko, Marta Kragel, Philip A Reis, Fernando MCV Ji, Shiyu Sehgal, Megha Maesta-Pereira, Sandra Chakerian, Meghmik Silva, Alcino J Canteras, Newton S Wager, Tor Kao, Jonathan C Adhikari, Avishek Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title | Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title_full | Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title_fullStr | Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title_full_unstemmed | Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title_short | Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
title_sort | dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457830/ https://www.ncbi.nlm.nih.gov/pubmed/34468312 http://dx.doi.org/10.7554/eLife.69178 |
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