Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether failures in the mitochondrial uptake of these nuclear-encoded proteins can cause proteotoxic stress...

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Detalles Bibliográficos
Autores principales: Nowicka, Urszula, Chroscicki, Piotr, Stroobants, Karen, Sladowska, Maria, Turek, Michal, Uszczynska-Ratajczak, Barbara, Kundra, Rishika, Goral, Tomasz, Perni, Michele, Dobson, Christopher M, Vendruscolo, Michele, Chacinska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457837/
https://www.ncbi.nlm.nih.gov/pubmed/34292154
http://dx.doi.org/10.7554/eLife.65484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457837/
https://www.ncbi.nlm.nih.gov/pubmed/34292154
http://dx.doi.org/10.7554/eLife.65484

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