Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study

A total of 2978 patients with validated paired results (SARS-CoV2-antigen and PCR) were identified. Our results show that only 45 antigen tests from 90 patients with positive validated PCR were correctly identified by antigen testing (sensitivity 50%). Roughly 50% of these patients had ongoing respi...

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Autores principales: Bräunlich, Jens, Hoheisel, Reimund, Dinse-Lambracht, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457903/
https://www.ncbi.nlm.nih.gov/pubmed/34656818
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115531
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author Bräunlich, Jens
Hoheisel, Reimund
Dinse-Lambracht, Alexander
author_facet Bräunlich, Jens
Hoheisel, Reimund
Dinse-Lambracht, Alexander
author_sort Bräunlich, Jens
collection PubMed
description A total of 2978 patients with validated paired results (SARS-CoV2-antigen and PCR) were identified. Our results show that only 45 antigen tests from 90 patients with positive validated PCR were correctly identified by antigen testing (sensitivity 50%). Roughly 50% of these patients had ongoing respiratory symptoms.
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spelling pubmed-84579032021-09-23 Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study Bräunlich, Jens Hoheisel, Reimund Dinse-Lambracht, Alexander Diagn Microbiol Infect Dis Article A total of 2978 patients with validated paired results (SARS-CoV2-antigen and PCR) were identified. Our results show that only 45 antigen tests from 90 patients with positive validated PCR were correctly identified by antigen testing (sensitivity 50%). Roughly 50% of these patients had ongoing respiratory symptoms. Elsevier Inc. 2022-01 2021-09-23 /pmc/articles/PMC8457903/ /pubmed/34656818 http://dx.doi.org/10.1016/j.diagmicrobio.2021.115531 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bräunlich, Jens
Hoheisel, Reimund
Dinse-Lambracht, Alexander
Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title_full Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title_fullStr Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title_full_unstemmed Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title_short Comparison of SARS-CoV-2 antigen testing to RT-PCR in a real-world setting—an observational cohort study
title_sort comparison of sars-cov-2 antigen testing to rt-pcr in a real-world setting—an observational cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457903/
https://www.ncbi.nlm.nih.gov/pubmed/34656818
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115531
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