An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting

The occurrence and severity of chemotherapy-induced nausea and vomiting (CINV) are influenced by many factors; this includes therapeutic factors, such as the dose, administration mode, and chemotherapeutic agent emetogenicity, as well as patient-related risk factors, such as the gender, age, alcohol...

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Detalles Bibliográficos
Autores principales: Jin, Yilan, Li, Xiaorong, Jiang, Caihong, Zhao, Jun, Liu, Guang, Li, Hui, Jin, Gaowa, Li, Quanfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458022/
https://www.ncbi.nlm.nih.gov/pubmed/34566427
http://dx.doi.org/10.2147/IJGM.S329257
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author Jin, Yilan
Li, Xiaorong
Jiang, Caihong
Zhao, Jun
Liu, Guang
Li, Hui
Jin, Gaowa
Li, Quanfu
author_facet Jin, Yilan
Li, Xiaorong
Jiang, Caihong
Zhao, Jun
Liu, Guang
Li, Hui
Jin, Gaowa
Li, Quanfu
author_sort Jin, Yilan
collection PubMed
description The occurrence and severity of chemotherapy-induced nausea and vomiting (CINV) are influenced by many factors; this includes therapeutic factors, such as the dose, administration mode, and chemotherapeutic agent emetogenicity, as well as patient-related risk factors, such as the gender, age, alcohol consumption history, and anxiety level. However, these factors cannot fully explain the individual CINV differences. In recent years, the correlation between gene polymorphism and CINV has been a hot research topic; the present paper reviews current research on CINV-related gene polymorphisms, and the results indicate that the use of gene polymorphism for the optimization of CINV efficacy is of important clinical significance.
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spelling pubmed-84580222021-09-23 An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting Jin, Yilan Li, Xiaorong Jiang, Caihong Zhao, Jun Liu, Guang Li, Hui Jin, Gaowa Li, Quanfu Int J Gen Med Review The occurrence and severity of chemotherapy-induced nausea and vomiting (CINV) are influenced by many factors; this includes therapeutic factors, such as the dose, administration mode, and chemotherapeutic agent emetogenicity, as well as patient-related risk factors, such as the gender, age, alcohol consumption history, and anxiety level. However, these factors cannot fully explain the individual CINV differences. In recent years, the correlation between gene polymorphism and CINV has been a hot research topic; the present paper reviews current research on CINV-related gene polymorphisms, and the results indicate that the use of gene polymorphism for the optimization of CINV efficacy is of important clinical significance. Dove 2021-09-18 /pmc/articles/PMC8458022/ /pubmed/34566427 http://dx.doi.org/10.2147/IJGM.S329257 Text en © 2021 Jin et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Jin, Yilan
Li, Xiaorong
Jiang, Caihong
Zhao, Jun
Liu, Guang
Li, Hui
Jin, Gaowa
Li, Quanfu
An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title_full An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title_fullStr An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title_full_unstemmed An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title_short An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting
title_sort update in our understanding of the relationships between gene polymorphisms and chemotherapy-induced nausea and vomiting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458022/
https://www.ncbi.nlm.nih.gov/pubmed/34566427
http://dx.doi.org/10.2147/IJGM.S329257
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