Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination

OBJECTIVE: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis (LN(met))....

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Detalles Bibliográficos
Autores principales: Sundar, Raghav, Liu, Drolaiz HW, Hutchins, Gordon GA, Slaney, Hayley L, Silva, Arnaldo NS, Oosting, Jan, Hayden, Jeremy D, Hewitt, Lindsay C, Ng, Cedric CY, Mangalvedhekar, Amrita, Ng, Sarah B, Tan, Iain BH, Tan, Patrick, Grabsch, Heike I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Stomach
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458060/
https://www.ncbi.nlm.nih.gov/pubmed/33229445
http://dx.doi.org/10.1136/gutjnl-2020-320805

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