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Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

OBJECTIVE: Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free cholesterol (FC) mediate hepatocyte injury, but their link in NASH has not been explored. We examined the role of free c...

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Detalles Bibliográficos
Autores principales:	Koh, Eun Hee, Yoon, Ji Eun, Ko, Myoung Seok, Leem, Jaechan, Yun, Ji-Young, Hong, Chung Hwan, Cho, Yun Kyung, Lee, Seung Eun, Jang, Jung Eun, Baek, Ji Yeon, Yoo, Hyun Ju, Kim, Su Jung, Sung, Chang Ohk, Lim, Joon Seo, Jeong, Won-Il, Back, Sung Hoon, Baek, In-Jeoung, Torres, Sandra, Solsona-Vilarrasa, Estel, Conde de la Rosa, Laura, Garcia-Ruiz, Carmen, Feldstein, Ariel E, Fernandez-Checa, Jose C, Lee, Ki-Up
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458090/ https://www.ncbi.nlm.nih.gov/pubmed/33208407 http://dx.doi.org/10.1136/gutjnl-2020-322509

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