A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potential. Their small size and stability mean that nanobodies are...

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Detalles Bibliográficos
Autores principales: Huo, Jiandong, Mikolajek, Halina, Le Bas, Audrey, Clark, Jordan J., Sharma, Parul, Kipar, Anja, Dormon, Joshua, Norman, Chelsea, Weckener, Miriam, Clare, Daniel K., Harrison, Peter J., Tree, Julia A., Buttigieg, Karen R., Salguero, Francisco J., Watson, Robert, Knott, Daniel, Carnell, Oliver, Ngabo, Didier, Elmore, Michael J., Fotheringham, Susan, Harding, Adam, Moynié, Lucile, Ward, Philip N., Dumoux, Maud, Prince, Tessa, Hall, Yper, Hiscox, Julian A., Owen, Andrew, James, William, Carroll, Miles W., Stewart, James P., Naismith, James H., Owens, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458290/
https://www.ncbi.nlm.nih.gov/pubmed/34552091
http://dx.doi.org/10.1038/s41467-021-25480-z

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