Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminished sonic hedgehog (Shh) signaling in the basal ganglia caused by the degeneration of midbrain dopami...

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Detalles Bibliográficos
Autores principales: Malave, Lauren, Zuelke, Dustin R., Uribe-Cano, Santiago, Starikov, Lev, Rebholz, Heike, Friedman, Eitan, Qin, Chuan, Li, Qin, Bezard, Erwan, Kottmann, Andreas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458306/
https://www.ncbi.nlm.nih.gov/pubmed/34552196
http://dx.doi.org/10.1038/s42003-021-02567-3

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