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Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study

BACKGROUND: Overuse and misuse of antibiotics is a public health problem in low-income and middle-income countries. Although the association of antibiotics with atopic and allergic diseases has been established, most studies focused on prenatal exposure and the occurrence of disease in infants or yo...

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Autores principales: Li, Yajia, Jing, Danrong, Huang, Yuzhou, Su, Juan, Li, Jie, Li, Ji, Tao, Juan, Shan, Shijun, Wang, Xiaohui, Kang, Xiaojing, Wu, Bin, Chen, Xiang, Shen, Minxue, Xiao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458315/
https://www.ncbi.nlm.nih.gov/pubmed/34548351
http://dx.doi.org/10.1136/bmjopen-2020-047768
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author Li, Yajia
Jing, Danrong
Huang, Yuzhou
Su, Juan
Li, Jie
Li, Ji
Tao, Juan
Shan, Shijun
Wang, Xiaohui
Kang, Xiaojing
Wu, Bin
Chen, Xiang
Shen, Minxue
Xiao, Yi
author_facet Li, Yajia
Jing, Danrong
Huang, Yuzhou
Su, Juan
Li, Jie
Li, Ji
Tao, Juan
Shan, Shijun
Wang, Xiaohui
Kang, Xiaojing
Wu, Bin
Chen, Xiang
Shen, Minxue
Xiao, Yi
author_sort Li, Yajia
collection PubMed
description BACKGROUND: Overuse and misuse of antibiotics is a public health problem in low-income and middle-income countries. Although the association of antibiotics with atopic and allergic diseases has been established, most studies focused on prenatal exposure and the occurrence of disease in infants or young children. OBJECTIVE: To investigate the association of preschool use of antibiotics with atopic and allergic skin diseases in young adulthood. DESIGN: Population-based retrospective cohort. SETTING AND PARTICIPANTS: The first-year college students (n=20 123) from five universities were investigated. The sampled universities are located in Changsha, Wuhan, Xiamen, Urumqi and Hohhot, respectively. METHODS: We conducted a dermatological field examination and a questionnaire survey inquiring the participants about the frequency of upper respiratory tract infection (URTI) and the preschool antibiotics use (prior to 7 years old). The two-level probit model was used to estimate the associations, and adjusted risk ratio (aRR) and 95% CI were presented as the effect size. RESULTS: A total of 20 123 participants with complete information was included in the final analysis. The frequent antibiotics use intravenously (aRR 1.36, 95% CI 1.14 to 1.62) and orally (aRR 1.18, 95% CI 1.01 to 1.38) prior to 7 years old was significantly associated with atopic dermatitis in young adulthood. Similar trends could be observed in allergic skin diseases among those who use antibiotics orally and intravenously, with RRs of 1.16 (95% CI 1.01 to 1.34) and 1.33 (95% CI 1.13 to 1.57), respectively. CONCLUSIONS: Preschool URTI and antibiotics use significantly increases the risk of atopic and allergic skin diseases in young adulthood.
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spelling pubmed-84583152021-10-07 Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study Li, Yajia Jing, Danrong Huang, Yuzhou Su, Juan Li, Jie Li, Ji Tao, Juan Shan, Shijun Wang, Xiaohui Kang, Xiaojing Wu, Bin Chen, Xiang Shen, Minxue Xiao, Yi BMJ Open Dermatology BACKGROUND: Overuse and misuse of antibiotics is a public health problem in low-income and middle-income countries. Although the association of antibiotics with atopic and allergic diseases has been established, most studies focused on prenatal exposure and the occurrence of disease in infants or young children. OBJECTIVE: To investigate the association of preschool use of antibiotics with atopic and allergic skin diseases in young adulthood. DESIGN: Population-based retrospective cohort. SETTING AND PARTICIPANTS: The first-year college students (n=20 123) from five universities were investigated. The sampled universities are located in Changsha, Wuhan, Xiamen, Urumqi and Hohhot, respectively. METHODS: We conducted a dermatological field examination and a questionnaire survey inquiring the participants about the frequency of upper respiratory tract infection (URTI) and the preschool antibiotics use (prior to 7 years old). The two-level probit model was used to estimate the associations, and adjusted risk ratio (aRR) and 95% CI were presented as the effect size. RESULTS: A total of 20 123 participants with complete information was included in the final analysis. The frequent antibiotics use intravenously (aRR 1.36, 95% CI 1.14 to 1.62) and orally (aRR 1.18, 95% CI 1.01 to 1.38) prior to 7 years old was significantly associated with atopic dermatitis in young adulthood. Similar trends could be observed in allergic skin diseases among those who use antibiotics orally and intravenously, with RRs of 1.16 (95% CI 1.01 to 1.34) and 1.33 (95% CI 1.13 to 1.57), respectively. CONCLUSIONS: Preschool URTI and antibiotics use significantly increases the risk of atopic and allergic skin diseases in young adulthood. BMJ Publishing Group 2021-09-21 /pmc/articles/PMC8458315/ /pubmed/34548351 http://dx.doi.org/10.1136/bmjopen-2020-047768 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Dermatology
Li, Yajia
Jing, Danrong
Huang, Yuzhou
Su, Juan
Li, Jie
Li, Ji
Tao, Juan
Shan, Shijun
Wang, Xiaohui
Kang, Xiaojing
Wu, Bin
Chen, Xiang
Shen, Minxue
Xiao, Yi
Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title_full Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title_fullStr Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title_full_unstemmed Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title_short Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
title_sort association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458315/
https://www.ncbi.nlm.nih.gov/pubmed/34548351
http://dx.doi.org/10.1136/bmjopen-2020-047768
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