The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies

Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs containing various constituents can transfer functional molecules from donor cells to recipient cells, thereby mediating intercellular communication. Noncod...

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Autores principales: Si, Lulu, Bai, Jing, Fu, Hanlin, Qiu, Haifeng, Guo, Ruixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458395/
https://www.ncbi.nlm.nih.gov/pubmed/34552067
http://dx.doi.org/10.1038/s41420-021-00645-3
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author Si, Lulu
Bai, Jing
Fu, Hanlin
Qiu, Haifeng
Guo, Ruixia
author_facet Si, Lulu
Bai, Jing
Fu, Hanlin
Qiu, Haifeng
Guo, Ruixia
author_sort Si, Lulu
collection PubMed
description Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs containing various constituents can transfer functional molecules from donor cells to recipient cells, thereby mediating intercellular communication. Noncoding RNAs (ncRNAs) are a type of RNA transcript with limited protein-coding capacity, that have been confirmed to be enriched in EVs in recent years. EV ncRNAs have become a hot topic because of their crucial regulating effect in disease progression, especially in cancer development. In this review, we summarized the biological functions of EV ncRNAs in the occurrence and progression of gynecological malignancies. In addition, we reviewed their potential applications in the diagnosis and treatment of gynecological malignancies.
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spelling pubmed-84583952021-10-07 The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies Si, Lulu Bai, Jing Fu, Hanlin Qiu, Haifeng Guo, Ruixia Cell Death Discov Review Article Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs containing various constituents can transfer functional molecules from donor cells to recipient cells, thereby mediating intercellular communication. Noncoding RNAs (ncRNAs) are a type of RNA transcript with limited protein-coding capacity, that have been confirmed to be enriched in EVs in recent years. EV ncRNAs have become a hot topic because of their crucial regulating effect in disease progression, especially in cancer development. In this review, we summarized the biological functions of EV ncRNAs in the occurrence and progression of gynecological malignancies. In addition, we reviewed their potential applications in the diagnosis and treatment of gynecological malignancies. Nature Publishing Group UK 2021-09-22 /pmc/articles/PMC8458395/ /pubmed/34552067 http://dx.doi.org/10.1038/s41420-021-00645-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Si, Lulu
Bai, Jing
Fu, Hanlin
Qiu, Haifeng
Guo, Ruixia
The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title_full The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title_fullStr The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title_full_unstemmed The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title_short The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
title_sort functions and potential roles of extracellular vesicle noncoding rnas in gynecological malignancies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458395/
https://www.ncbi.nlm.nih.gov/pubmed/34552067
http://dx.doi.org/10.1038/s41420-021-00645-3
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