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Reversible insulin resistance helps Bactrian camels survive fasting

Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was si...

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Autores principales: Guo, Fucheng, Si, Rendalai, Li, Quanyun, Hai, Le, Yi, Li, He, Jing, Ming, Liang, Ji, Rimutu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458433/
https://www.ncbi.nlm.nih.gov/pubmed/34552154
http://dx.doi.org/10.1038/s41598-021-98234-y
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author Guo, Fucheng
Si, Rendalai
Li, Quanyun
Hai, Le
Yi, Li
He, Jing
Ming, Liang
Ji, Rimutu
author_facet Guo, Fucheng
Si, Rendalai
Li, Quanyun
Hai, Le
Yi, Li
He, Jing
Ming, Liang
Ji, Rimutu
author_sort Guo, Fucheng
collection PubMed
description Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was significantly downregulated in the fore hump and hind hump during the fasting period. In addition, there was no difference in serum insulin levels among the three stages. However, the serum leptin and adiponectin levels decreased significantly during fasting. Additionally, insulin tolerance tests during the three stages showed that camels were insensitive to insulin during fasting. Further study of the serum metabolites showed that serum branched-chain and aromatic amino acid levels increased during the fasting period. Finally, analysis of microbial diversity in camel faeces at different stages showed that during the fasting period, the proportion of Firmicutes and Actinobacteria increased, while that of Bacteroides and the butyrate-producing bacterium Roseburia decreased. The results of this study show that fasting is accompanied by changes in the activation of insulin pathways in various camel tissues, normal insulin levels, and increased lipolysis and insulin resistance, which return to normal after eating.
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spelling pubmed-84584332021-09-24 Reversible insulin resistance helps Bactrian camels survive fasting Guo, Fucheng Si, Rendalai Li, Quanyun Hai, Le Yi, Li He, Jing Ming, Liang Ji, Rimutu Sci Rep Article Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was significantly downregulated in the fore hump and hind hump during the fasting period. In addition, there was no difference in serum insulin levels among the three stages. However, the serum leptin and adiponectin levels decreased significantly during fasting. Additionally, insulin tolerance tests during the three stages showed that camels were insensitive to insulin during fasting. Further study of the serum metabolites showed that serum branched-chain and aromatic amino acid levels increased during the fasting period. Finally, analysis of microbial diversity in camel faeces at different stages showed that during the fasting period, the proportion of Firmicutes and Actinobacteria increased, while that of Bacteroides and the butyrate-producing bacterium Roseburia decreased. The results of this study show that fasting is accompanied by changes in the activation of insulin pathways in various camel tissues, normal insulin levels, and increased lipolysis and insulin resistance, which return to normal after eating. Nature Publishing Group UK 2021-09-22 /pmc/articles/PMC8458433/ /pubmed/34552154 http://dx.doi.org/10.1038/s41598-021-98234-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Guo, Fucheng
Si, Rendalai
Li, Quanyun
Hai, Le
Yi, Li
He, Jing
Ming, Liang
Ji, Rimutu
Reversible insulin resistance helps Bactrian camels survive fasting
title Reversible insulin resistance helps Bactrian camels survive fasting
title_full Reversible insulin resistance helps Bactrian camels survive fasting
title_fullStr Reversible insulin resistance helps Bactrian camels survive fasting
title_full_unstemmed Reversible insulin resistance helps Bactrian camels survive fasting
title_short Reversible insulin resistance helps Bactrian camels survive fasting
title_sort reversible insulin resistance helps bactrian camels survive fasting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458433/
https://www.ncbi.nlm.nih.gov/pubmed/34552154
http://dx.doi.org/10.1038/s41598-021-98234-y
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