Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of r...

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Detalles Bibliográficos
Autores principales: Heestermans, Marco, Naudin, Clément, Mailer, Reiner K., Konrath, Sandra, Klaetschke, Kristin, Jämsä, Anne, Frye, Maike, Deppermann, Carsten, Pula, Giordano, Kuta, Piotr, Friese, Manuel A., Gelderblom, Mathias, Sickmann, Albert, Preston, Roger J. S., Nofer, Jerzy-Roch, Rose-John, Stefan, Butler, Lynn M., Salomon, Ophira, Stavrou, Evi X., Renné, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458485/
https://www.ncbi.nlm.nih.gov/pubmed/34552086
http://dx.doi.org/10.1038/s41467-021-25888-7

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