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Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing

Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we d...

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Autores principales: Chen, Binyao, Zhu, Lei, Yang, Shizhao, Su, Wenru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458576/
https://www.ncbi.nlm.nih.gov/pubmed/34566965
http://dx.doi.org/10.3389/fimmu.2021.711329
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author Chen, Binyao
Zhu, Lei
Yang, Shizhao
Su, Wenru
author_facet Chen, Binyao
Zhu, Lei
Yang, Shizhao
Su, Wenru
author_sort Chen, Binyao
collection PubMed
description Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we discuss in detail the remarkable perspectives in DC reclassification and ontogeny as revealed by scRNA-seq. Moreover, the heterogeneity and multifunction of DCs during diseases as determined by scRNA-seq are described. Finally, we provide insights into the challenges and future trends in scRNA-seq technologies and DC research.
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spelling pubmed-84585762021-09-24 Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing Chen, Binyao Zhu, Lei Yang, Shizhao Su, Wenru Front Immunol Immunology Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we discuss in detail the remarkable perspectives in DC reclassification and ontogeny as revealed by scRNA-seq. Moreover, the heterogeneity and multifunction of DCs during diseases as determined by scRNA-seq are described. Finally, we provide insights into the challenges and future trends in scRNA-seq technologies and DC research. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458576/ /pubmed/34566965 http://dx.doi.org/10.3389/fimmu.2021.711329 Text en Copyright © 2021 Chen, Zhu, Yang and Su https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Binyao
Zhu, Lei
Yang, Shizhao
Su, Wenru
Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title_full Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title_fullStr Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title_full_unstemmed Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title_short Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
title_sort unraveling the heterogeneity and ontogeny of dendritic cells using single-cell rna sequencing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458576/
https://www.ncbi.nlm.nih.gov/pubmed/34566965
http://dx.doi.org/10.3389/fimmu.2021.711329
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