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P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury

Few objective indices can be used when evaluating neurocognitive disorders after a traumatic brain injury (TBI). P300 has been widely studied in mental disorders, cognitive dysfunction, and brain injury. Daily life ability and social function are key indices in the assessment of neurocognitive disor...

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Autores principales: Li, Haozhe, Li, Ningning, Xing, Yan, Zhang, Shengyu, Liu, Chao, Cai, Weixiong, Hong, Wu, Zhang, Qinting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458648/
https://www.ncbi.nlm.nih.gov/pubmed/34566838
http://dx.doi.org/10.3389/fneur.2021.690792
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author Li, Haozhe
Li, Ningning
Xing, Yan
Zhang, Shengyu
Liu, Chao
Cai, Weixiong
Hong, Wu
Zhang, Qinting
author_facet Li, Haozhe
Li, Ningning
Xing, Yan
Zhang, Shengyu
Liu, Chao
Cai, Weixiong
Hong, Wu
Zhang, Qinting
author_sort Li, Haozhe
collection PubMed
description Few objective indices can be used when evaluating neurocognitive disorders after a traumatic brain injury (TBI). P300 has been widely studied in mental disorders, cognitive dysfunction, and brain injury. Daily life ability and social function are key indices in the assessment of neurocognitive disorders after a TBI. The present study focused on the correlation between P300 and impairment of daily living activity and social function. We enrolled 234 patients with neurocognitive disorders after a TBI according to ICD-10 and 277 age- and gender-matched healthy volunteers. The daily living activity and social function were assessed by the social disability screening schedule (SDSS) scale, activity of daily living (ADL) scale, and scale of personality change following a TBI. P300 was evoked by a visual oddball paradigm. The results showed that the scores of the ADL scale, SDSS scale, and scale of personality change in the patient group were significantly higher than those in the control group. The amplitudes of Fz, Cz, and Pz in the patient group were significantly lower than those in the control group and were negatively correlated with the scores of the ADL and SDSS scales. In conclusion, a lower P300 amplitude means a greater impairment of daily life ability and social function, which suggested more severity of neurocognitive disorders after a TBI. P300 could be a potential indicator in evaluating the severity of neurocognitive disorders after a TBI.
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spelling pubmed-84586482021-09-24 P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury Li, Haozhe Li, Ningning Xing, Yan Zhang, Shengyu Liu, Chao Cai, Weixiong Hong, Wu Zhang, Qinting Front Neurol Neurology Few objective indices can be used when evaluating neurocognitive disorders after a traumatic brain injury (TBI). P300 has been widely studied in mental disorders, cognitive dysfunction, and brain injury. Daily life ability and social function are key indices in the assessment of neurocognitive disorders after a TBI. The present study focused on the correlation between P300 and impairment of daily living activity and social function. We enrolled 234 patients with neurocognitive disorders after a TBI according to ICD-10 and 277 age- and gender-matched healthy volunteers. The daily living activity and social function were assessed by the social disability screening schedule (SDSS) scale, activity of daily living (ADL) scale, and scale of personality change following a TBI. P300 was evoked by a visual oddball paradigm. The results showed that the scores of the ADL scale, SDSS scale, and scale of personality change in the patient group were significantly higher than those in the control group. The amplitudes of Fz, Cz, and Pz in the patient group were significantly lower than those in the control group and were negatively correlated with the scores of the ADL and SDSS scales. In conclusion, a lower P300 amplitude means a greater impairment of daily life ability and social function, which suggested more severity of neurocognitive disorders after a TBI. P300 could be a potential indicator in evaluating the severity of neurocognitive disorders after a TBI. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458648/ /pubmed/34566838 http://dx.doi.org/10.3389/fneur.2021.690792 Text en Copyright © 2021 Li, Li, Xing, Zhang, Liu, Cai, Hong and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Haozhe
Li, Ningning
Xing, Yan
Zhang, Shengyu
Liu, Chao
Cai, Weixiong
Hong, Wu
Zhang, Qinting
P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title_full P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title_fullStr P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title_full_unstemmed P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title_short P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury
title_sort p300 as a potential indicator in the evaluation of neurocognitive disorders after traumatic brain injury
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458648/
https://www.ncbi.nlm.nih.gov/pubmed/34566838
http://dx.doi.org/10.3389/fneur.2021.690792
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