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MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in...

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Autores principales: Clarke, Laura, Arnett, Simon, Bukhari, Wajih, Khalilidehkordi, Elham, Jimenez Sanchez, Sofia, O'Gorman, Cullen, Sun, Jing, Prain, Kerri M., Woodhall, Mark, Silvestrini, Roger, Bundell, Christine S., Abernethy, David A., Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brownlee, Wallace, Butzkueven, Helmut, Carroll, William M., Chen, Cella, Coulthard, Alan, Dale, Russell C., Das, Chandi, Fabis-Pedrini, Marzena J., Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P. D., Heshmat, Saman, Hodgkinson, Suzanne, Kilpatrick, Trevor J., King, John, Kneebone, Christopher, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming-Wei, Lynch, Christopher, Macdonell, Richard A. L., Mason, Deborah F., McCombe, Pamela A., Pereira, Jennifer, Pollard, John D., Ramanathan, Sudarshini, Reddel, Stephen W., Shaw, Cameron P., Spies, Judith M., Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G. K., Marriott, Mark P., Parratt, John D. E., Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Brilot, Fabienne, Vincent, Angela, Waters, Patrick, Broadley, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458658/
https://www.ncbi.nlm.nih.gov/pubmed/34566866
http://dx.doi.org/10.3389/fneur.2021.722237
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author Clarke, Laura
Arnett, Simon
Bukhari, Wajih
Khalilidehkordi, Elham
Jimenez Sanchez, Sofia
O'Gorman, Cullen
Sun, Jing
Prain, Kerri M.
Woodhall, Mark
Silvestrini, Roger
Bundell, Christine S.
Abernethy, David A.
Bhuta, Sandeep
Blum, Stefan
Boggild, Mike
Boundy, Karyn
Brew, Bruce J.
Brownlee, Wallace
Butzkueven, Helmut
Carroll, William M.
Chen, Cella
Coulthard, Alan
Dale, Russell C.
Das, Chandi
Fabis-Pedrini, Marzena J.
Gillis, David
Hawke, Simon
Heard, Robert
Henderson, Andrew P. D.
Heshmat, Saman
Hodgkinson, Suzanne
Kilpatrick, Trevor J.
King, John
Kneebone, Christopher
Kornberg, Andrew J.
Lechner-Scott, Jeannette
Lin, Ming-Wei
Lynch, Christopher
Macdonell, Richard A. L.
Mason, Deborah F.
McCombe, Pamela A.
Pereira, Jennifer
Pollard, John D.
Ramanathan, Sudarshini
Reddel, Stephen W.
Shaw, Cameron P.
Spies, Judith M.
Stankovich, James
Sutton, Ian
Vucic, Steve
Walsh, Michael
Wong, Richard C.
Yiu, Eppie M.
Barnett, Michael H.
Kermode, Allan G. K.
Marriott, Mark P.
Parratt, John D. E.
Slee, Mark
Taylor, Bruce V.
Willoughby, Ernest
Brilot, Fabienne
Vincent, Angela
Waters, Patrick
Broadley, Simon A.
author_facet Clarke, Laura
Arnett, Simon
Bukhari, Wajih
Khalilidehkordi, Elham
Jimenez Sanchez, Sofia
O'Gorman, Cullen
Sun, Jing
Prain, Kerri M.
Woodhall, Mark
Silvestrini, Roger
Bundell, Christine S.
Abernethy, David A.
Bhuta, Sandeep
Blum, Stefan
Boggild, Mike
Boundy, Karyn
Brew, Bruce J.
Brownlee, Wallace
Butzkueven, Helmut
Carroll, William M.
Chen, Cella
Coulthard, Alan
Dale, Russell C.
Das, Chandi
Fabis-Pedrini, Marzena J.
Gillis, David
Hawke, Simon
Heard, Robert
Henderson, Andrew P. D.
Heshmat, Saman
Hodgkinson, Suzanne
Kilpatrick, Trevor J.
King, John
Kneebone, Christopher
Kornberg, Andrew J.
Lechner-Scott, Jeannette
Lin, Ming-Wei
Lynch, Christopher
Macdonell, Richard A. L.
Mason, Deborah F.
McCombe, Pamela A.
Pereira, Jennifer
Pollard, John D.
Ramanathan, Sudarshini
Reddel, Stephen W.
Shaw, Cameron P.
Spies, Judith M.
Stankovich, James
Sutton, Ian
Vucic, Steve
Walsh, Michael
Wong, Richard C.
Yiu, Eppie M.
Barnett, Michael H.
Kermode, Allan G. K.
Marriott, Mark P.
Parratt, John D. E.
Slee, Mark
Taylor, Bruce V.
Willoughby, Ernest
Brilot, Fabienne
Vincent, Angela
Waters, Patrick
Broadley, Simon A.
author_sort Clarke, Laura
collection PubMed
description Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), “bright spotty” (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS.
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spelling pubmed-84586582021-09-24 MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis Clarke, Laura Arnett, Simon Bukhari, Wajih Khalilidehkordi, Elham Jimenez Sanchez, Sofia O'Gorman, Cullen Sun, Jing Prain, Kerri M. Woodhall, Mark Silvestrini, Roger Bundell, Christine S. Abernethy, David A. Bhuta, Sandeep Blum, Stefan Boggild, Mike Boundy, Karyn Brew, Bruce J. Brownlee, Wallace Butzkueven, Helmut Carroll, William M. Chen, Cella Coulthard, Alan Dale, Russell C. Das, Chandi Fabis-Pedrini, Marzena J. Gillis, David Hawke, Simon Heard, Robert Henderson, Andrew P. D. Heshmat, Saman Hodgkinson, Suzanne Kilpatrick, Trevor J. King, John Kneebone, Christopher Kornberg, Andrew J. Lechner-Scott, Jeannette Lin, Ming-Wei Lynch, Christopher Macdonell, Richard A. L. Mason, Deborah F. McCombe, Pamela A. Pereira, Jennifer Pollard, John D. Ramanathan, Sudarshini Reddel, Stephen W. Shaw, Cameron P. Spies, Judith M. Stankovich, James Sutton, Ian Vucic, Steve Walsh, Michael Wong, Richard C. Yiu, Eppie M. Barnett, Michael H. Kermode, Allan G. K. Marriott, Mark P. Parratt, John D. E. Slee, Mark Taylor, Bruce V. Willoughby, Ernest Brilot, Fabienne Vincent, Angela Waters, Patrick Broadley, Simon A. Front Neurol Neurology Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), “bright spotty” (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458658/ /pubmed/34566866 http://dx.doi.org/10.3389/fneur.2021.722237 Text en Copyright © 2021 Clarke, Arnett, Bukhari, Khalilidehkordi, Jimenez Sanchez, O'Gorman, Sun, Prain, Woodhall, Silvestrini, Bundell, Abernethy, Bhuta, Blum, Boggild, Boundy, Brew, Brownlee, Butzkueven, Carroll, Chen, Coulthard, Dale, Das, Fabis-Pedrini, Gillis, Hawke, Heard, Henderson, Heshmat, Hodgkinson, Kilpatrick, King, Kneebone, Kornberg, Lechner-Scott, Lin, Lynch, Macdonell, Mason, McCombe, Pereira, Pollard, Ramanathan, Reddel, Shaw, Spies, Stankovich, Sutton, Vucic, Walsh, Wong, Yiu, Barnett, Kermode, Marriott, Parratt, Slee, Taylor, Willoughby, Brilot, Vincent, Waters and Broadley. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Clarke, Laura
Arnett, Simon
Bukhari, Wajih
Khalilidehkordi, Elham
Jimenez Sanchez, Sofia
O'Gorman, Cullen
Sun, Jing
Prain, Kerri M.
Woodhall, Mark
Silvestrini, Roger
Bundell, Christine S.
Abernethy, David A.
Bhuta, Sandeep
Blum, Stefan
Boggild, Mike
Boundy, Karyn
Brew, Bruce J.
Brownlee, Wallace
Butzkueven, Helmut
Carroll, William M.
Chen, Cella
Coulthard, Alan
Dale, Russell C.
Das, Chandi
Fabis-Pedrini, Marzena J.
Gillis, David
Hawke, Simon
Heard, Robert
Henderson, Andrew P. D.
Heshmat, Saman
Hodgkinson, Suzanne
Kilpatrick, Trevor J.
King, John
Kneebone, Christopher
Kornberg, Andrew J.
Lechner-Scott, Jeannette
Lin, Ming-Wei
Lynch, Christopher
Macdonell, Richard A. L.
Mason, Deborah F.
McCombe, Pamela A.
Pereira, Jennifer
Pollard, John D.
Ramanathan, Sudarshini
Reddel, Stephen W.
Shaw, Cameron P.
Spies, Judith M.
Stankovich, James
Sutton, Ian
Vucic, Steve
Walsh, Michael
Wong, Richard C.
Yiu, Eppie M.
Barnett, Michael H.
Kermode, Allan G. K.
Marriott, Mark P.
Parratt, John D. E.
Slee, Mark
Taylor, Bruce V.
Willoughby, Ernest
Brilot, Fabienne
Vincent, Angela
Waters, Patrick
Broadley, Simon A.
MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title_full MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title_fullStr MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title_full_unstemmed MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title_short MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
title_sort mri patterns distinguish aqp4 antibody positive neuromyelitis optica spectrum disorder from multiple sclerosis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458658/
https://www.ncbi.nlm.nih.gov/pubmed/34566866
http://dx.doi.org/10.3389/fneur.2021.722237
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