The GH-IGF-1 Axis in Circadian Rhythm

Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with th...

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Autores principales: Wang, Weihao, Duan, Xiaoye, Huang, Zhengxiang, Pan, Qi, Chen, Chen, Guo, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458700/
https://www.ncbi.nlm.nih.gov/pubmed/34566581
http://dx.doi.org/10.3389/fnmol.2021.742294
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author Wang, Weihao
Duan, Xiaoye
Huang, Zhengxiang
Pan, Qi
Chen, Chen
Guo, Lixin
author_facet Wang, Weihao
Duan, Xiaoye
Huang, Zhengxiang
Pan, Qi
Chen, Chen
Guo, Lixin
author_sort Wang, Weihao
collection PubMed
description Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the change of the clock system may be related to the pulsatile release of GH. The GH—insulin-like growth factor 1 (IGF-1) axis and clock system may interact further on the metabolism through regulatory pathways in peripheral organs. We have summarized the current clinical and animal evidence on the interaction of clock systems with the GH—IGF-1 axis and discussed their effects on metabolism.
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spelling pubmed-84587002021-09-24 The GH-IGF-1 Axis in Circadian Rhythm Wang, Weihao Duan, Xiaoye Huang, Zhengxiang Pan, Qi Chen, Chen Guo, Lixin Front Mol Neurosci Neuroscience Organisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the change of the clock system may be related to the pulsatile release of GH. The GH—insulin-like growth factor 1 (IGF-1) axis and clock system may interact further on the metabolism through regulatory pathways in peripheral organs. We have summarized the current clinical and animal evidence on the interaction of clock systems with the GH—IGF-1 axis and discussed their effects on metabolism. Frontiers Media S.A. 2021-09-09 /pmc/articles/PMC8458700/ /pubmed/34566581 http://dx.doi.org/10.3389/fnmol.2021.742294 Text en Copyright © 2021 Wang, Duan, Huang, Pan, Chen and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Weihao
Duan, Xiaoye
Huang, Zhengxiang
Pan, Qi
Chen, Chen
Guo, Lixin
The GH-IGF-1 Axis in Circadian Rhythm
title The GH-IGF-1 Axis in Circadian Rhythm
title_full The GH-IGF-1 Axis in Circadian Rhythm
title_fullStr The GH-IGF-1 Axis in Circadian Rhythm
title_full_unstemmed The GH-IGF-1 Axis in Circadian Rhythm
title_short The GH-IGF-1 Axis in Circadian Rhythm
title_sort gh-igf-1 axis in circadian rhythm
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458700/
https://www.ncbi.nlm.nih.gov/pubmed/34566581
http://dx.doi.org/10.3389/fnmol.2021.742294
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